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Abstract
This article reviews what is currently known about short tandem repeat (STR) allelic sequence variation in and around the twenty-four loci most commonly used throughout the world to perform forensic DNA investigations. These STR loci include D1S1656, TPOX, D2S441, D2S1338, D3S1358, FGA, CSF1PO, D5S818, SE33, D6S1043, D7S820, D8S1179, D10S1248, TH01, vWA, D12S391, D13S317, Penta E, D16S539, D18S51, D19S433, D21S11, Penta D, and D22S1045. All known reported variant alleles are compiled along with genomic information available from GenBank, dbSNP, and the 1000 Genomes Project. Supplementary files are included which provide annotated reference sequences for each STR locus, characterize genomic variation around the STR repeat region, and compare alleles present in currently available STR kit allelic ladders. Looking to the future, STR allele nomenclature options are discussed as they relate to next generation sequencing efforts underway.
Keywords
: STR Allele Sequence Variation: Current Knowledg
Future Issues
Author: Katherine Butler Gettings Rachel A. Aponte Peter M.
Vallone John M. Butler
PII: S1872-4973(15)30026-0
DOI: http://dx.doi.org/doi:10.1016/j.fsigen.2015.06.005
Reference: FSIGEN 1368
To appear in: Forensic Science International: Genetics
Received date: 13-2-2015
Revised date: 20-5-2015
Accepted date: 10-6-2015
Please cite this article as: Katherine Butler Gettings, Rachel A.Aponte,
Peter M.Vallone, John M.Butler, STR Allele Sequence Variation: Current
Knowledge and Future Issues, Forensic Science International: Genetics
http://dx.doi.org/10.1016/j.fsigen.2015.06.005
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Forensic DNA; Short tandem repeat; STR loci; DNA database; Sequence variation; STR nomenclature
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