MalonylMalonyl CoACoA
ATP; ATP;
COCO
22
ADP ADP ++ PiPi
HSHS ACP (E*)ACP (E*)
1
AcetylAcetyl CoACoA
AcetoacetylAcetoacetyl EE**
AcetylAcetyl EE**
HydroxyHydroxy ButyrylButyryl E*E*
DehydroDehydro AcylAcyl E*E*
Butyryl Butyryl E*E*
AcylAcyl E*E* ((C<16C<16))
MalonylMalonyl E*E*
+ (n+ (n 1)Malonyl1)Malonyl E*E*
2
3
CO
2
HSHS ACP (E*)ACP (E*)
4
5
6
4 - Khử Ceto
5 - Loại H
2
O
6 - Khử lần 2
H
2

*
Acid béo
HOOC- CH
2
- CO~S-CoA
AcylCoA (AcylCoA (C<16C<16) )
 ëë ty thÓty thÓ
+ V/c Acid bÐo (C <16) tõ bµo t¬ng + V/c Acid bÐo (C <16) tõ bµo t¬ng > Ty thÓ> Ty thÓ
+ + ≠≠ ëë bµo t¬ng: Nèi dµi b»ng bµo t¬ng: Nèi dµi b»ng AcetylAcetyl CoA CoA
CoE: NADPHCoE: NADPH
22
/ NADH/ NADH
22
+ KÕt qu¶: tæng hîp AB (C > 16)+ KÕt qu¶: tæng hîp AB (C > 16)
Ty thÓ Mµng ty thÓ Bµo t¬ng
OxaloacetatOxaloacetat
KrebsKrebs
HSCoAHSCoA
AB (C>16)AB (C>16) << AcylCoAAcylCoA
Acyl CarnitinAcyl Carnitin
Carnitin CarnitinCarnitin Carnitin
AcetylAcetyl CoACoA
Acetyl CarnitinAcetyl Carnitin
AcetylAcetyl CoACoA
CitratCitratCitratCitrat CitratCitrat
(1)
- “O”
ATP
Pi + ADP
HSCoA


R
1
R
2
OH
TG.lipase
R
3
COOH
DG.lipase
R
1
COOH
OH
R
2
OH
Đồng phân
hoá
TG
DG
MG


MG
OH
R
2
OH