1
5Ӕ,/2Ҥ17+Ө7+ӆ7<526,1(.,1$6(
7521*&È&%ӊ1+81*7+Ѭ
TS.BS. +2¬1*$1+9lj
Ĉ̹LKͥF<'́ͻF7KjQKSKͩ+ͫ&Kt0LQK

2
1. 7Ә1*48È7
2. FLT3 7521*81*7+Ѭ0È8
3. EGFR 7521*81*7+Ѭ3+Ә,9¬81*7+ѬĈҤ,75Ӵ&75¬1*
4. HER-2/neu 7521*81*7+Ѭ9Ò
5. KIT 9¬PDGFRA 7521*80ÐĈӊ0ĈѬӠ1*7,Ç8+Ï$
1ӝLGXQJ
3
1. 7Ә1*48È7
2. FLT3 7521*81*7+Ѭ0È8
3. EGFR 7521*81*7+Ѭ3+Ә,9¬81*7+ѬĈҤ,75Ӵ&75¬1*
4. HER-2/neu 7521*81*7+Ѭ9Ò
5. KIT 9¬PDGFRA 7521*80ÐĈӊ0ĈѬӠ1*7,Ç8+Ï$
1ӝLGXQJ
4
0Ð+Î1+ĈѪ1*,Ҧ19ӄ758<ӄ1
7Ë1+,ӊ81Ӝ,%¬2
5
7+Ө7+ӆ%ӄ0Һ79¬7+Ө7+ӆ1Ӝ,%¬2
6
&È&.,ӆ87ѬѪ1*7È&*,Ӳ$/,*$1'9¬
7+Ө7+ӆ
7
7ӂ%¬27Ӗ17Ҥ,ĈѬӦ&1+Ӡ7Ë1+,ӊ8
1*2Ҥ,%¬2

p
p
PI3K
CBL
SHP2
SHIP
GAB2
AKT
FOXO3A
JAK2
Membrane
Activated
FLT3
Cytoplasm
16
Transmembrane
Tyrosine kinase I
Tyrosine kinase II
Extracellular
Juxtamembrane
Cell proliferation and differentiation
FLT3 is target for
selective inhibition
ĈӜ7%,ӂ1FLT3 7521*81*7+Ѭ0È8
1. Insertion (ITD)
2. Point mutations
3. Point mutations
Frequency
AML MDS
ALL