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Copyright © 2008, New Age International (P) Ltd., Publishers
Published by New Age International (P) Ltd., Publishers
All rights reserved.
No part of this ebook may be reproduced in any form, by photostat, microfilm,
xerography, or any other means, or incorporated into any information retrieval
system, electronic or mechanical, without the written permission of the publisher.
All inquiries should be emailed to
PUBLISHING FOR ONE WORLD
NEW AGE INTERNATIONAL (P) LIMITED, PUBLISHERS
4835/24, Ansari Road, Daryaganj, New Delhi - 110002
Visit us at www.newagepublishers.com
ISBN (13) : 978-81-224-2627-4
Dedicated to
PROF. DR. F.V. MANVI
SecretarySecretary
SecretarySecretary
Secretary
KLE Society, BELGAUM
KARNATAKA.
“To My First Pharmacy teacher with Love”
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FOREWORDFOREWORD
FOREWORDFOREWORD

exhaustive Question bank of around 5000 MCQs with answers covering a wide spectrum of basic Biochemical topics of
the subject.
Some of the important topics which are given a good coverage include Carbohydrate metabolism, Protein metabo-
lism, Lipid metabolism, Nucleic acids, Enzymes, Vitamins and Mineral metabolism.
The objective questions are prepared based on the background taken from previous question papers of Profes-
sional medical and Paramedical competitive entrance examinations.
The book serves as a ready reckoner for Biochemistry as far as objective pattern is concerned. I feel satisfied if the
book serves the purpose for which it is intended.
I have tried to minimize typographical errors but still some must have crept in. If they are brought to my notice, I will
be rectifying them in the next edition.
Constructive Criticism is always welcome
G. Vidya Sagar
AA
AA
A
CKNOWLEDGEMENTSCKNOWLEDGEMENTS
CKNOWLEDGEMENTSCKNOWLEDGEMENTS
CKNOWLEDGEMENTS
I wish to express my profound gratitude and benevolence to the following who were the inspiring force in making this
book a reality
• Sadhvi Shilapiji
Chair person, Veerayatan Vidyapeeth,
Jakhaniya, Kutch, Gujarat
• Prof. Dr. R.K. Goyal
L.M. College of Pharmacy
Ahmedabad, Gujarat
• Prof. Dr. A.K. Saluja
A.R. College of Pharmacy
Vallabh Vidyanagar
Gujarat

Principal, Goa College of Pharmacy, Goa.
Biochemistry made simple in the form of multiple choice questions. Strongly recommended.
Prof. Dr. Vijaykumar Ishwar Hukkeri
Principal, KLE College of Pharmacy, Hubli
Dr. Vidya Sagar can be applauded for his untiring efforts in bringing out such a good book.
Recommended for students and Library
Dr. G. Devala Rao
Principal, Sidhartha College of Pharmaceutical Sciences
Vijaywada, A.P.
This book will be very useful companion for students appearing for PG Medical, Pharmacy, Nursing and
Physiotherapy competitive exams.
Prof. Dr. T.K. Ravi
Principal, Sri Ramakrishna Institute of Pharmaceutical Science
Coimbatore.
MCQs are well framed, mostly from previous entrance examinations. Commendable work.
Prof. Madhukar R. Tajne
Deptt. of Pharmaceutical Sciences,
Nagpur University, Nagpur
CC
CC
C
ONTENTSONTENTS
ONTENTSONTENTS
ONTENTS
Preface (x)
Chapter 1
INTRODUCTION TINTRODUCTION T
INTRODUCTION TINTRODUCTION T
INTRODUCTION T
O BIOCHEMISTRYO BIOCHEMISTRY

TEIN MET
ABOLISMABOLISM
ABOLISMABOLISM
ABOLISM
2727
2727
27
CHAPTER 4
FF
FF
F
AA
AA
A
TS & FTS & F
TS & FTS & F
TS & F
AA
AA
A
TTY ATTY A
TTY ATTY A
TTY A
CID METCID MET
CID METCID MET
CID MET
ABOLISMABOLISM
ABOLISMABOLISM
ABOLISM
7575

HORMONE METHORMONE MET
HORMONE METHORMONE MET
HORMONE MET
ABOLISMABOLISM
ABOLISMABOLISM
ABOLISM
209209
209209
209
CHAPTER 9
NUCLEIC ANUCLEIC A
NUCLEIC ANUCLEIC A
NUCLEIC A
CIDSCIDS
CIDSCIDS
CIDS
237237
237237
237
CHAPTER 10
WW
WW
W
AA
AA
A
TER & ELECTROLTER & ELECTROL
TER & ELECTROLTER & ELECTROL
TER & ELECTROL
YTE BALANCEYTE BALANCE

IOCHEMISTRYIOCHEMISTRY
IOCHEMISTRY
1. A drug which prevents uric acid synthesis
by inhibiting the enzyme xanthine
oxidase is
(A) Aspirin (B) Allopurinol
(C) Colchicine (D) Probenecid
2. Which of the following is required for
crystallization and storage of the
hormone insulin?
(A) Mn
++
(B) Mg
++
(C) Ca
++
(D) Zn
++
3. Oxidation of which substance in the body
yields the most calories
(A) Glucose (B) Glycogen
(C) Protein (D) Lipids
4. Milk is deficient in which vitamins?
(A) Vitamin C (B) Vitamin A
(C) Vitamin B
2
(D) Vitamin K
5. Milk is deficient of which mineral?
(A) Phosphorus (B) Sodium
(C) Iron (D) Potassium

(A) The hydroxyl group is located near the centre
of the lipid layer
(B) Most of the cholesterol is in the form of a
cholesterol ester
(C) The steroid nucleus form forms a rigid, planar
structure
MCQs IN BIOCHEMISTRY
2
(D) The hydrocarbon chain of cholesterol projects
into the extracellular fluid
12. Which one is the heaviest particulate
component of the cell?
(A) Nucleus (B) Mitochondria
(C) Cytoplasm (D) Golgi apparatus
13. Which one is the largest particulate of the
cytoplasm?
(A) Lysosomes
(B) Mitochondria
(C) Golgi apparatus
(D) Entoplasmic reticulum
14. The degradative Processess are categorized
under the heading of
(A) Anabolism (B) Catabolism
(C) Metabolism (D) None of the above
15. The exchange of material takes place
(A) Only by diffusion
(B) Only by active transport
(C) Only by pinocytosis
(D) All of these
16. The average pH of Urine is

(C) All of these
21. The most active site of protein synthesis
is the
(A) Nucleus (B) Ribosome
(C) Mitochondrion (D) Cell sap
22. The fatty acids can be transported into
and out of mitochondria through
(A) Active transport
(B) Facilitated transfer
(C) Non-facilitated transfer
(D) None of these
23. Mitochondrial DNA is
(A) Circular double stranded
(B) Circular single stranded
(C) Linear double helix
(D) None of these
24. The absorption of intact protein from the
gut in the foetal and newborn animals
takes place by
(A) Pinocytosis (B) Passive diffusion
(C) Simple diffusion (D) Active transport
25. The cellular organelles called “suicide
bags” are
(A) Lysosomes (B) Ribosomes
(C) Nucleolus (D) Golgi’s bodies
26. From the biological viewpoint, solutions
can be grouped into
(A) Isotonic solution
(B) Hypotonic solutions
(C) Hypertonic solution

(C) They form intracellular conducting channels
(D) They are involved in muscle cell contraction
33. The following substances are cell
inclusions except
(A) Melanin (B) Glycogen
(C) Lipids (D) Centrosome
34. Fatty acids can be transported into and
out of cell membrane by
(A) Active transport (B) Facilitated transport
(C) Diffusion (D) Osmosis
35. Enzymes catalyzing electron transport
are present mainly in the
(A) Ribosomes
(B) Endoplasmic reticulum
(C) Lysosomes
(D) Inner mitochondrial membrane
36. Mature erythrocytes do not contain
(A) Glycolytic enzymes(B) HMP shunt enzymes
(C) Pyridine nucleotide(D) ATP
37. In mammalian cells rRNA is produced
mainly in the
(A) Endoplasmic reticulum
(B) Ribosome
(C) Nucleolus
(D) Nucleus
38. Genetic information of nuclear DNA is
transmitted to the site of protein synthesis
by
(A) rRNA (B) mRNA
(C) tRNA (D) Polysomes

O
n
(C) C
n
H
2
O
2n
(D) C
n
H
2n
O
2n
2. The general formula of polysaccharides
is
(A) (C
6
H
10
O
5
)
n
(B) (C
6
H
12
O
5

(C) Arabinose (D) Xylose
7. Polysaccharides are
(A) Polymers (B) Acids
(C) Proteins (D) Oils
8. The number of isomers of glucose is
(A) 2 (B) 4
(C) 8 (D) 16
CHAPTER 2CHAPTER 2
CHAPTER 2CHAPTER 2
CHAPTER 2
CC
CC
C
ARBOHYDRAARBOHYDRA
ARBOHYDRAARBOHYDRA
ARBOHYDRA
TESTES
TESTES
TES
ANDAND
ANDAND
AND
CC
CC
C
ARBOHYDRAARBOHYDRA
ARBOHYDRAARBOHYDRA

12.
αα
αα
α-D-glucose and
β
-D-glucose are
(A) Stereoisomers (B) Epimers
(C) Anomers (D) Keto-aldo pairs
13.
αα
αα
α-D-glucose + 112
0
→
+ 52.5
0
←
+ 19
0

ββ
ββ
β-
D-glucose for glucose above represents
(A) Optical isomerism (B) Mutarotation
(C) Epimerisation (D) D and L isomerism
14. Compounds having the same structural
formula but differing in spatial
configuration are known as
(A) Stereoisomers (B) Anomers

(A) Ribose (B) Deoxyribose
(C) Ribulose (D) Erythrose
22. The sugar found in milk is
(A) Galactose (B) Glucose
(C) Fructose (D) Lactose
23. Invert sugar is
(A) Lactose (B) Sucrose
(C) Hydrolytic products of sucrose
(D) Fructose
24. Sucrose consists of
(A) Glucose + glucose
(B) Glucose + fructose
(C) Glucose + galactose
(D) Glucose + mannose
25. The monosaccharide units are linked by
1
→→
→→
→ 4 glycosidic linkage in
(A) Maltose (B) Sucrose
(C) Cellulose (D) Cellobiose
26. Which of the following is a non-reducing
sugar?
(A) Isomaltose (B) Maltose
(C) Lactose (D) Trehalose
27. Which of the following is a reducing
sugar?
(A) Sucrose (B) Trehalose
(C) Isomaltose (D) Agar
28. A dissaccharide formed by 1,1-glycosidic

35. The polysaccharide found in the
exoskeleton of invertebrates is
(A) Pectin (B) Chitin
(C) Cellulose (D) Chondroitin sulphate
36. Which of the following is a heteroglycan?
(A) Dextrins (B) Agar
(C) Inulin (D) Chitin
37. The glycosaminoglycan which does not
contain uronic acid is
(A) Dermatan sulphate
(B) Chondroitin sulphate
(C) Keratan sulphate
(D) Heparan sulphate
38. The glycosaminoglycan which does not
contain uronic acid is
(A) Hyaluronic acid
(B) Heparin
(C) Chondroitin sulphate
(D) Dermatan sulphate
39. Keratan sulphate is found in abundance
in
(A) Heart muscle (B) Liver
(C) Adrenal cortex (D) Cornea
40. Repeating units of hyaluronic acid are
(A) N-acetyl glucosamine and D-glucuronic acid
(B) N-acetyl galactosamine and D-glucuronic
acid
(C) N-acetyl glucosamine and galactose
(D) N-acetyl galactosamine and L- iduronic acid
41. The approximate number of branches in

49. A positive Seliwanoff’s test is obtained
with
(A) Glucose (B) Fructose
(C) Lactose (D) Maltose
50. Osazones are not formed with the
(A) Glucose (B) Fructose
(C) Sucrose (D) Lactose
51. The most abundant carbohydrate found
in nature is
(A) Starch (B) Glycogen
(C) Cellulose (D) Chitin
52. Impaired renal function is indicated when
the amount of PSP excreted in the first 15
minutes is
(A) 20% (B) 35%
(C) 40% (D) 45%
53. An early feature of renal disease is
(A) Impairment of the capacity of the tubule to
perform osmotic work
MCQs IN BIOCHEMISTRY
8
(B) Decrease in maximal tubular excretory
capacity
(C) Decrease in filtration factor
(D) Decrease in renal plasma flow
54. ADH test is based on the measurement of
(A) Specific gravity of urine
(B) Concentration of urea in urine
(C) Concentration of urea in blood
(D) Volume of urine in ml/minute

(A) Hyaluronic acid (B) Chondroitin sulphate
(C) Heparin (D) All of these
62. Fructose is present in hydrolysate of
(A) Sucrose (B) Inulin
(C) Both of the above (D) None of these
63. A carbohydrate found in DNA is
(A) Ribose (B) Deoxyribose
(C) Ribulose (D) All of these
64. Ribulose is a these
(A) Ketotetrose (B) Aldotetrose
(C) Ketopentose (D) Aldopentose
65. A carbohydrate, commonly known as
dextrose is
(A) Dextrin (B) D-Fructose
(C) D-Glucose (D) Glycogen
66. A carbohydrate found only in milk is
(A) Glucose (B) Galactose
(C) Lactose (D) Maltose
67. A carbohydrate, known commonly as
invert sugar, is
(A) Fructose (B) Sucrose
(C) Glucose (D) Lactose
68. A heteropolysacchraide among the
following is
(A) Inulin (B) Cellulose
(C) Heparin (D) Dextrin
69. The predominant form of glucose in
solution is
(A) Acyclic form
(B) Hydrated acyclic form

αα
α-Glycosidic bond is present in
(A) Lactose (B) Maltose
(C) Sucrose (D) All of these
76. Branching occurs in glycogen approxi-
mately after every
(A) Five glucose units
(B) Ten glucose units
(C) Fifteen glucose units
(D) Twenty glucose units
77. N–Acetylglucosamnine is present in
(A) Hyaluronic acid (B) Chondroitin sulphate
(C) Heparin (D) All of these
78. Iodine gives a red colour with
(A) Starch (B) Dextrin
(C) Glycogen (D) Inulin
79. Amylose is a constituent of
(A) Starch (B) Cellulose
(C) Glycogen (D) None of these
80. Synovial fluid contains
(A) Heparin
(B) Hyaluronic acid
(C) Chondroitin sulphate
(D) Keratin sulphate
81. Gluconeogenesis is decreased by
(A) Glucagon (B) Epinephrine
(C) Glucocorticoids (D) Insulin
82. Lactate formed in muscles can be utilised
through
(A) Rapoport-Luebeling cycle

(C) Digoxin (D) Alloxan
90. Glucose-6-phosphatase is absent or
deficient in
(A) Von Gierke’s disease
(B) Pompe’s disease
(C) Cori’s disease
(D) McArdle’s disease
MCQs IN BIOCHEMISTRY
10
91. Debranching enzyme is absent in
(A) Cori’s disease
(B) Andersen’s disease
(C) Von Gierke’s disease
(D) Her’s disease
92. McArdle’s disease is due to the deficiency
of
(A) Glucose-6-phosphatase
(B) Phosphofructokinase
(C) Liver phosphorylase
(D) muscle phosphorylase
93. Tautomerisation is
(A) Shift of hydrogen (B) Shift of carbon
(C) Shift of both (D) None of these
94. In essential pentosuria, urine contains
(A) D-Ribose (B) D-Xylulose
(C) L-Xylulose (D) D-Xylose
95. Action of salivary amylase on starch leads
to the formation of
(A) Maltose (B) Maltotriose
(C) Both of the above (D) Neither of these

+
(B) NAD
+
: NADH
(C) FADH
2
: FAD (D) FAD : FADH
2
103. Ethanol decreases gluconeogenesis by
(A) Inhibiting glucose-6-phosphatase
(B) Inhibiting PEP carboxykinase
(C) Converting NAD
+
into NADH and decreasing
the availability of pyruvate
(D) Converting NAD
+
into NADH and decreasing
the availability of lactate
104. Glycogenin is
(A) Uncoupler of oxidative phosphorylation
(B) Polymer of glycogen molecules
(C) Protein primer for glycogen synthesis
(D) Intermediate in glycogen breakdown
105. During starvation, ketone bodies are used
as a fuel by
(A) Erythrocytes (B) Brain
(C) Liver (D) All of these
106. Animal fat is in general
(A) Poor in saturated and rich in polyunsaturated

(C) Cirrhosis of liver (D) Peptic ulcer
112. Polyuria can occur in
(A) Diabetes mellitus
(B) Diarrhoea
(C) Acute glomerulonephritis
(D) High fever
113. Normal specific gravity of urine is
(A) 1.000–1.010 (B) 1.012–1.024
(C) 1.025–1.034 (D) 1.035–1.045
114. Specific gravity of urine is raised in all of
the following except
(A) Diabetes mellitus
(B) Diabetes insipidus
(C) Dehydration
(D) Acute glomerulonephritis
115. Specific gravity of urine is decreased in
(A) Diabetes mellitus
(B) Acute glomerulonephritis
(C) Diarrhoea
(D) Chronic glomerulonephritis
116. Heavy proteinuria occurs in
(A) Acute glomerulonephritis
(B) Acute pyelonephritis
(C) Nephrosclerosis
(D) Nephrotic syndrome
117. Mucopolysaccharides are
(A) Hamopolysaccharides
(B) Hetropolysaccharides
(C) Proteins
(D) Amino acids

12
O
5
)
n
(D) (C
6
H
19
O
6
)
n
122. The number of isomers of glucose is
(A) 4 (B) 8
(C) 12 (D) 16
123. The epimers of glucose is
(A) Fructose (B) Galactose
(C) Ribose (D) Deoxyribose
124. The intermediate in hexose monophos-
phate shunt is
(A) D-Ribolose (B) D-Arobinose
(C) D-xylose (D) D-lyxose
125. Honey contains the hydrolytic product of
(A) Lactose (B) Maltose
(C) Inulin (D) Starch
126. On boiling Benedict’s solution is not
reduced by
(A) Sucrose (B) Lactose
(C) Maltose (D) Fructose

(C) 34–40 (D) 44–50
135. N-acetylneuraminic acid is an example of
(A) Sialic acid (B) Mucic acid
(C) Glucuronic acid (D) Hippuric acid
136. In place of glucuronic acid chondroitin
sulphate B contains
(A) Gluconic acid (B) Gulonic acid
(C) Induronic acid (D) Sulphonic acid
137. Blood group substances consist of
(A) Lactose (B) Maltose
(C) Fructose (D) Mucose
138. The component of cartilage and cornea is
(A) Keratosulphate
(B) Chondroitin sulphate
(C) Cadmium sulphate
(D) Antimony sulphate
139. Benedict’s test is less likely to give weakly
positive results with concentrated urine
due to the action of
(A) Urea (B) Uric acid
(C) Ammonium salts (D) Phosphates
140. Active transport of sugar is depressed by
the agent:
(A) Oxaloacetate (B) Fumarate
(C) Malonate (D) Succinate
141. The general test for detection of
carbohydrates is
(A) Iodine test (B) Molisch test
(C) Barfoed test (D) Osazone test
142. Glucose absorption may be decreased in