NGHIEN
cCru TONG
HOP
SAN
PHAM
NGl/NG TU CLIA
GLUCOZAMINCLOHYDRAT V6l MOT SO HOP CHAT
CHLTA
NHOM AMINO
Nguyen Thi Thanh Phong, Phan Quang Thai
Khna Hoa hoc
Tririmg
DHSP -
DHQG
Ha
Ngi
I. Ma dau
Nu6e
ta eo san
lirong
hai san noi chung
vei
san
luiTng
tom noi rieng
dude
danh bat hang
nam
rttt
Ion,
irdfc

vi
vSy,
trong bai
nay chung toi
mudn d6
cap den mot so san
philm ngimg
tu giua glucozaminclohydrat vdi
thiosemicacbazit, axit
glutiimie
va
cixit
aspatie.
II.
Thirc
nghiem
Qua trinh tach chitin va
chuySn
thanh glucozaminclohydrat da duoc
ehiing
toi dang trong
eOng trinh
[1].
Phan
ung
ngung tu giua glucozaminclohydrat va mot so hop chat
chura nhdm
NH2
dirge
thue

vao do 10ml ete.
Ket tiia dirge
tach ra eo mau
v;uig
nhat,
Ige
lay
kfi't tiia
va lam kh6 san
phin
b
nhifit
do
thich
hgp.
196
a^on
j-o
r/
'•"
'NHCI
3
2
K
n.
2
miu chtf sSn phin
ngung tu giiia Glucozaminclohydrat
v^
axit glutamic (Glu - N -

b^g
c6n
tuyft
ddi,
Uten khO s&n phim 6
nhiet
d6 thich
hgp.
n.3
Di^u cM phiia
ngung
tii
giua glucozaminclohydrat
v^
axit
aspatie
(Glu - N - Asp.).
CSch didu
ch^
tuong
tii
nhu
di^u
ch^
Glu - N - Glut
&
tren.
III.
Ket qua va thao
luan

i
I Itai iiitti
<iili« M A«t>
€11*
Jit
2t:*
1
.1
3(i
'IH
«i:i
Phdn dng
ngung tu
cd Vhk nSng xky
ra theo 2 giai doan
dd la c6ng vJi
t^ch.
DQ
nhdm
*NH3
hut electron manh
diJng
canh nhdm C = 0 nhdm dd
1^
tang dien tfch duong
d cdcbon
cabonyl
di^u
dd tao
di^u

phdm,
ta cd the nhan thay
sir
khae nhau kha ro
(bang 1), chung to cac phan ung xay ra theo du doan.
III.2.
Bien
lugn
ve pho hong ngogi cua cac san
phani
ngimg tu.
Nhin chung phd hong ngoai
ciia
cac chat nghien
cuu diu xu^t
hien cac pie dac trung cho
dao ddng hoa tri va dao dong bien dang cua cac nhdm
chiJc
trong phan
tir chSft
dau va cac san
phdm
(bang 2).
Tren bang 2 chung
la d6
dang nhan thay ngoai cac pic dac trung cua Glu, con xuat hien
cac pie mdi dac trung cho dao dong hoa tri
ciia
nhdm
iizometin

1.
Nguyen Thi Thanh Phong, Phan Quang Thai, Nghien
ciJii
tach,
ehuye'n
hoa chitin
thanh axit glucozaminic va boat tfnh sinh hoc cua Fe
(II)
Glucozaminat,
tuydn
tap bao cao Hoi
nghj
Hoa hoc toan qudc
Ian thii
3, tr.
160-161,
Ha Ngi 1998.
2.
Nguyen Ngge Tu, Bao cao khoa hoe tai
Hdi
nghi Vien Hoa hoc
Ian
thu"
II, Ha Ndi,
ngay 22
thdng
2 nam 1995.
3.
G. A. F. Roberts and J. G.
Domszy inl