Luận văn:Medsoft, deciphering principles of transcription regulation in eukaryotic genomes : Luận văn ThS. Công nghệ thông tin: 1 01 10
Nhà xuất bản:ĐHCN
Ngày:2008
Chủ đề:Giải mã
Gen
Nhiễm sắc thể
Phần mềm y học
Công nghệ thông tin
Miêu tả:50 tr. + CD-ROM
Luận văn ThS. Khoa học máy tính -- Trường đại học Công nghệ. Đại học Quốc gia Hà Nội, 2008
Regulation of transcription plays an important role on organismal complexity and diversity during biological evolution and adaptation. The dependency of transcription regulation on quantitative behaviors of cis-regulatory elements (CREs) is considered as a function of promoter context. Thus, understanding principles of CRE behavior in regulating transcriptional process is crucially significant for quantitative biology. The recent work of Nguyen and D’haeseleer shed a light on the principles. In this thesis, we aim to develop a computer program which is based on Nguyen and D’haeseleer approaches to analyze CREs (motifs). MEDSoft is applied to Saccharomyces cerevisiae transcriptional networks, and detects regulatory functions for all motifs present in the yeast S. cerevisiae genomes as recently determined experimentally by chromatin immunoprecipitation
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