Chapter 019. Fever of Unknown Origin
(Part 7)

Acknowledgments
Sheldon M. Wolff, MD, now deceased, was an author of a previous version
of this chapter. It is to his memory that the chapter is dedicated. The substantial
contributions of Charles A. Dinarello, MD, to this chapter in previous editions are
gratefully acknowledged.
Further Readings
Bleeker-
Rovers CP et al: A prospective multicenter study on fever of
unknown origin: The yield of a structured diagnostic protocol. Medicine 86:26,
2007 [PMID: 17220753]
de Kleijn EM
et al: Fever of unknown origin (FUO): I. A prospective
multicenter study of 167 patients with FUO, using fixed epidemiologic entry
criteria. Medicine 76:392, 1997
———
et al: Fever of unknown origin (FUO): II. Diagnostic procedures in
a prospective multicenter study of 167 patients. Medicine 76:401, 1997
Goto M et al: A retrospective review of 226 hospitalized patients with
fever. Intern Med 46:17, 2007 [PMID: 17202728]
Hirschmann JV: Fever of unknown origin in adults. Clin Infect Dis
24:291,
1997 [PMID: 9114175]
Hughes WT et al: 2002 guidelines for the use of antimicrobial agents in
neutropenic patients with cancer. Clin Infect Dis 34:730, 2002 [PMID: 11850858]

Knockaert DC et al: Fever of unknown origin in adults: 40 years on. J
Intern Med 253:263, 2003 [PMID: 12603493]
Mourad O et al: A comprehensive evidence-

Kazanjian P
H: Fever of unknown origin: Review of 86 patients treated in
community hospitals. Clin Infect Dis 15:968, 1992 [PMID: 1457669]
Knockaert DC et al: Long-term follow-
up of patients with undiagnosed
fever of unknown origin. Arch Intern Med 156:618, 1996 [PMID: 8629872]
Knockaert DC, Vanneste LJ: Fever of unknown origin in elderly patients. J
Am Geriatr Soc 41:1187, 1993 [PMID: 8227892]
———
, Vanneste LJ: Fever of unknown origin in the 1980s. Arch Intern
Med 152:51, 1992
Larson EB, Featherstone HJ: Fever
of undetermined origin: Diagnosis and
follow-up of 105 cases, 1970–80. Medicine 61:269, 1982 [PMID: 6287162]
Palacios G et al: Panmicrobial oligonucleotide array for diagnosis of
infectious diseases. Emerg Infect Dis 13:73, 2007 [PMID: 17370518]
Peaco
ck JE et al: Ciprofloxacin plus piperacillin compared with tobramycin
plus piperacillin as empirical therapy in febrile neutropenic patients. Ann Intern
Med 137:77, 2002 [PMID: 12118962]
Petersdorf RC, Beeson PB: Fever of unexplained origin. Medicine 40:
1,
1961 [PMID: 13734791]
Volk EE et al: The diagnostic usefulness of bone marrow cultures in
patients with fever of unknown origin. Am J Clin Pathol 110:150, 1998 [PMID:
9704612]