BO
mi UQC M& SHUUG liOC
QliMlil.
LmSliJ^
ZKUQtJU VAl aOC
i-QlJU
ilQP
li/,
i.Ui
MMSJA SMih
HOC
M*
S
4
»
N»
SKAK
TI4IIU AN
K.vai^4ri
VAI 'i'itO CWi
01;
Uiii-
*x»ivU.U VU
i.^U
i^Ul
VOl
aU liHUl
i^iW-H
sum iiiiiil
C^k
2IAL0 iuWlku

1
U
Riaii
II
T(JNG
iiUAN TAI LlS;U
I-
Cd
s3
hinh
thai
cua cac
qua
trlnh -&c
che
d ndroa
!• Te bao
tiTunf^
gian Uc chc trong
vo
nao
2.
GAM - chat
trimg ^an
TSC
che trong vo nao
5»
Cau
true modun va cau true tjp qu-szi
II-

tlch
xuc
giec vibriss
17-
Dan ligu
ve
ve;l
tro 5c che
doi vci
b\?
ulnii
thanl-i tirjh
chat cua ndron vo
noc.
Treng
9-57
9-20
21-26
:6-32
32-57
Phan III
PHt/OlvG
PHAP
J«GHl£f^
Cl/U 5b-51
I-
Chuan
"bj.
d^ng
vit thx

nh§y
cam theo hudng
4.
Tinh th3i
gian
tiem
tang
V-
ChUdng trinlri thye ng;h i§iQ
38-39
30-51
«
3 -
Phan
lY
Trang
KUT
(4UA NGfilfiN CtfU 52-111
Chx&jng
I
3^-70
©AC
Tim
DAP
Ul^G
CUA
I^OROi.^
VraG
VO
ISAO

Phan tfng cua ndron khi
kich
thich cac
s<Ji
vibriss
6^70
khac nhau trong
tnr3ug
thy
cam*
Chijfdng
II
71-'&4
bU BIETi iiOI Tlim NHAY
CAM
THH) EUDfiG
CUA
NOHON
DUOI
TAG
DVnO
CUA
KICH
THICK
i>OI,Ai^£i
HUONG CUA
Y£U
TO
TiiOI
GIAN

hiidng*
2.
Sy
thay doi
tinh nhgiy
cam theo
hUdng
d cac ndron
nguyen
phat
nh§y
cam theo
hUdng.
II-
Inh
h^:fdng
cua yeu to
th8i
gian doi vdi sy bien doi
77-60
tinh nh^y
cam theo
hxrdng
cua ndron.
1.
t?y xuat hi^n
giai
do^
t'iam
dap

KHOWG
GI.J^
TBDm tJU
BIEN DOI
Tliai NHAY Qtili
ThiiX;
HUOriG
-
4
-
I-
inh hu3ng
cua
hvTdng kich
thich dieu khien doi
v5i 85-87
dap ting
hu:ng*
II-
by
bien doi tinh
nh§iy
cam theo hudng cua cac ndron
87-*00
dtr^i
tac
dyng
cua kich thich dieu khien
len
cac

Sy thay doi tinh
nh§y
cam theo
htfdng
cua ndron khi
kich
thich dieu khien tac
dgng
vao
s^i
vibriss
nlm
khac hang
vdi fi^i
chj.u
kich thich
hxhag.
Chtfdng
IV 101-111
TAG
DU14G
CUA
PICROTOXIK i)OI
VOI
THUGITG THU
CAii VA SU
II£I^
^01 TI^iti
KHAY
CM:

cam theo
htidng
2.
Doi v5i cac
ndj^on
nguyen phat khong
nh§y
cam theo
hiidng
III-
By bien doi
th3i
gian tiem tang cua phan
Ung dxtSi
108-11
anh
htfdng
cua picrotoxin.
Phan IV
MJK
fipH
K£T
qui
112-129
I- Ve
d|c
tinh
dap
ung
cua cac ndron

cam theo
hi/dng
cua ndron. 120-129
!• by
tich
h^g
ve
th3i
gian
2.
Tich
h;;p
ve
Idiong
gian.
Ph^
V
K f
T
LJJ I
^ 130-131
Phan VI
~*~ Ll|nJ Thm
KHIO
132-148
« 3«
aiMi • ^
C^n^
v^
«tf

diSu khl^n phtfc
tpp
va
h9an
bao
nh'u cua gl^i ty cbi3a«
ItbJmg;
vin de cc?
ban va co
clnb of:.uyeo cic nhif
qua
trlnh
tfcb bffp cac lu^ne btfiJng cdD»
vol
trS
cua qua
trlnb
^c chl tronf
bop^
<7<^Q£'
pbon xp cS dllu
kl^,
qu^
triob hiob
th&nh V9 duy trl
tri
oh^,v*v«**
tvt ISu iis Xitiu
hut
3^

ban
cbic cti»a
qua
trlnb tic
ebl«
eui^
nbi/
cc^
chl
yult
billn^
phat ^ridn
VB
uac dime
ttn:^Dg bd
cua qua
trJnb
nay
v5l
qua trlnh
ht?ng pbln oht? tbl
nao,
thl
troo^'
su^t
o^t
tbo^i gian dal vln
c^
chiia
dif^^

nao
b0,
B«
trtr^c bic
la
sy blnb tbaob
cac quo trlnb
then kinb ccf
ban
dam
bao cbo nao
b<^
t;byc
bi^o cbuc nang
tbdri^-
tin
«
dieu
kbl4n
cua
slnb
(la,
19, 39,
31^
32,
51»
^^,
137,
155)#
Tbeo

(9) vo do do da
laa
nlly
sinb sy
cln tbiec phai »es xet lai kh^i nigm kinb dieo
vS trur&ng tby ca©t
coi
trtr&tig
thy cam cua
neuron
la
tS ch5c
«
6
«
ctfoe
able,
dtfcfc
blab tbanb
obo'
sy
guy
ty
co
cbpn Ipc ohtmg
loSng xung di^Dg btf5ag tS© dl tli
cac
td cb5c
than
klnh thip

vo nao
tbi giac
(66,
67,
IJ^^t^iSS}
va vo
oao cao gioo-^ona (9)«
Hgoai
re
COQ
CO
y
kiln cbo
rln{r ay bile dSl **mls
deo*
trottg fahmp ©li
quan b|
tt»ng
tac
gil/a
c5c
acfron
dl
tpo ra
ay linh bo^t troog
vo nao
cung la nh&
qua trlob
^ cbl
(16,

cbit
d^i
icbaoe
(ootagwiitta)
cua
geiw»a-oa5ino-*utyric-axtt
(UAES)
vao
tl
bao tb§Q
kinb.
£|c
qua
ogaien
c5u cbo
thiy ay pbong toa
Se
cbl
Be Xao mit t£nb chit
detector cua
nifron
(V,
&3)
•
Bgi;PQ^c
lal,
cung
bSng pfaiJcmg
pbap vl
di#n

kit
qua
la^
arixat
bl0»,
bo§c tba:7 ddl tlnb
nbay
cas tbeo bti5ng cim
cac
t;l
bao
tbap*
•I tllp tyc
tl©
bllu val
tro 5c chl trong vo
oao
d^l
v5l
sy
hltxb
thnnb
tfnh
nbay
c^a
theo
hvtm^
cua
coc nc?ron
vung

thanb
eac
tinh cbit
cua
oxyroo
vung cam
giac^aoffla*
Md blnb
tbufin lyl
cbo
vifc nc^bign c5u noy
la
b# tblog
ttbfty
cao
xuc giac
rSu eao
(vlbrlse)*
Val tro cua
5o
cbl trong vo nao
d<!l
v^l
sy blnb tbanb
cac
tlab cbit cuo cc^on
vung
cis giac-aoma se
co
tbd

thlcb
hi^^g tSs
do
kich
thlcb dllu
kbllo gfiy
ra*
% sis bllu anb bii^ag
cua
ylu
tl
th^l
gian
dll
v^l
ay
biln 66l
tlab
obpy eioD
tbeo
hiring
cua
ac^on»
4*
IPhSm tlcb d$c tinh kbdug
gian cua
ay biln
doi
tlnb
nbay

chit
cua 5c cbl
va
val tro cua no
del v5i ay
blnb tbanb cac
tfnh cblt
nay cua
nc^on*
^*btmg kit
quo
thu diiyc
trong
c6nt"
trlnb
nghiSn
c5u
nay cbo
thIy
rang t
- t5c
cbl
troog
vo nao do
kich
thlcb
hb^mxe t§a tao
re
^B
lam

ho|ic
oo,
nbi/n^;
o'
ni5c
C^
khori^;
cao#
-
QtQ? lult
1*ay
ddl
tlnb
nbay ca^a cheo hu$tis
cua
no?ron
pby tbu§c
vao cac ylu
tS thJl
gian va
khdcc
gian
cua coc
klcb
thich*
«*
vi oSt ly chuylt nbDng kit
qua tbu
diiyc
coo

cua vo nao,
din
tlnb
cblt oua nc^on
va val tro
cua 5c cbl trong vo
nao*
Dgc bi^t
cac
ddn llfu
vl blnb
tbnl bpc
da
g^
pban
dang
kl
vao
vi|c glal qii^lt
cac
vln
di
trSn.
3/^
CQ
go
mm
m^i
mj
t^np

czuc typ
quan
(anaeffible)
cos
nc^n*
3^*
2l bSo
trun^:
fzimn
5c
chg
tram-
vj a»o
clu
true
vl
bao
vo nao da
duyc nghlSn cuu tb ISu
,
nbtfng
y
ngbia ch5c
nan£^
cua
tSuf^
loai te
l^o
vo val tro
cua Chung trong

chuyen boa va la
ca cbIt
cua quo trlnh 5c cbl (17,19,
20»
21, 49,
3X,
34t 115»
122,
150)*
Do
tfnh
cbIt
da dgng cua tl
bao
blnb
sao
va do klcb
tbiioc
cua than tl
bao gu;?
nbo,
nen vigc ph&n lopl
tryc
tllp cac tl bao 5c cbl trong vo nao ca vl
mgt
cb5c
n^ng
va
blnb thai
diu rSc

TnfSc hit
i^tfol
ta chu
y
dio
clu
true
cua
xlnop»
f^ao
l^Jt?^
Gray
(1^1
)
v5l
phtfo^g
pbap
c3 dj.nb
va
nhu^a
to cb5c than
klnh kbl nghlSn
e5u
nhd klrh
bien vl
di$n
tu da
pbgt hign
vo
ud

CO
kba 3clnap
b^p
hc^n,
vvn^^
boat
dgnf^
hep va
khong
CO
phan
5n^
v5l
acetylcbolln.
3ov
do
nSo
1^65
tcblznov (157) chi
ro
tMm lopi
I co
coc
tui yinop hlnb
tron,
con loal
I-^
co cac
tul srloap
blnb

ci:u
ylu
0 cr6n
than cua tl boo
nay,
6
tleu
nao
xlnap loal
i-£
t^p
trung;
tv^ti thSn ciia
te
bso pin:*klnj€
(73)•
'^beo
cac tac
ela
tr^n,
srlnop loal I
la
yinop
b.rng
ph*n,
con
xluap loal XI
la
:<inop
5c

xlnsp
5c che
do
chlln v} trl tbugn lyl nhit
trong
vl^c
dllu
h^o
qua trlnb
pbat
xun^^;
cue
no^n.
Iron£;
so cac
cl bso
soo,
uu boo ry
thuvn^-
tgo m xlnop
a
11
«
lopl II trSn
tb3n tl
uoo ubap
(la.,
123,
130)« fixoo
cua tl

rang s tl boo
irp
co trong
tit CO
coc vung vo nao
©51
va
lo
tl bao
trun^:
eloa
5c che
(13,
19,
61,
9i^.
la,
132,
14G).
Can c5
voo
clu
true vs
d^c
dies
phan
nbanh,
o^m
1975
^ntagoth^l

1^
IIX-V
cua vo
noo,
hh%n
d|nb
nay
cun{;
phu hyp
v5l
y
kiln
cuo
^orlQ-i'adilo
(1-i).
hi^ixiSc
c5u clu
true
cua tl
b^o
rp
tron^^
v^g
v^
d^Jng
vo nao
nt:i/&l»
tac
f:;ia
tb*y

ti*oof:
phlln«
6
noo
khf,
naci
l^jf73
Glons(ll>)
cuut^
quoa
sot
thIy
coc
bl
boo
lopi
i
V5 I05I
Vi,
tu'cync
ty
nhif
cl boo rp
l5n
vo rp nho cua
Sentogouhal»
Cbun*:^
P^^-^n
nhonb
cbu ylu

blgu
qua 5c cbl the
hlgn
ro
c'
coc
nc^rdn nhm
tpoof
bmt)s:
vuctttj £0c v5l ranh chtf tb^p
(7,
^)m
sit hyp phiKfnc
pbap
cbyp
onb ty
d^n^
bing phong xg
,
pbi/otig
pbap
Golgl
Va
klnh bile
vl
dlyn
tii,
esc toe
gla fib|t
Ban (147,

gloc
5c chl
tron^j,
vo nao,
TbSn cua
Coc tl bao
noy
nlo
trong
Ic^
H,
xll
•
/ixon
cuo tl boo toa nhanh tbanb
hlnb
nhi/
chile den cbuc
(49,
1^,
150)
vo
too
re coc xlnap
lool II
tllp xuc
v&i dopn dIu ax«i
cua tl
baO
tbap

anb
b*ng
phong
x©,
coc coc gla
cuasf,
thIy
boa
chit
trw5g gian
cua coc xlnap nay lo
GiiBA#
Ttf
cac din
ll§u
tren, co
thi kit lu0n rln^s
trong vo
nao
CO nhllu
cl bao
trur-r;
gian,
Ve
nguygn
t:1c,
coc tl bao
nay co kha
nang gfiy
5c chl coc tl

vo do do dllu boo qua trlnb
tpo xunp
cua tl bao
t;bop«
2.
G/>r.4- cbit
trum-
glnn
5c chl
tronr
vo
n.r|Q
.
Kbllu
y
kiln
cho
ring chit
trung
gian
5c chl
ct^
ban
tront
vo
aoo
la
gaomo-afflla^-'butyrlc-oxlt
(>,
5, 58,

xj donh ciu (Ir - GABA)
Iversen va
c^nc
sif (112
,
113) cbo
blet,
khoang
70 >v chit
nay
t|ip
trun^^
a t?n cung
tban klnh, 11
>» trSn syl
khdUt:
co myelin, 11
v^
trin dendrlu
va
6 ^ ti'Sn
cl boo
ijlia*
3y
tip
trung
OAB^
nhlSu
trong
t#n

Ifin
g^
3
Ian
so
v5l
l5c
cbtia
kich
thlcb»
IJIU
kb5
ion
Ca**^
tronf;
cd
than
kinb
ohl
khi klcb thlcb vo nao
nSnt
d^J
QiiBA
khong
tling ISn
«
Dllu noy
cb5ng
to
Gn"*^

la chit
d^n
truyin
trong
xlnap 5c chl cua
vo.nno,
I^htfoG
tbl
nfchifiD dtPo
coc
chic vao
tl boo bang
phtfcfng
pbap vl
dl^n
di
(mlcz-oelectrophoaras
application) cua
Knlevlc
(116,
117,
IIB)
va
Alexandrov
(3,
4,
5)
da thu
dtfyc kit
qua

glSy.
Dwl
anb
hiWng
cua dong
dl§fl
dl
GAB^,
co
earns d$
20
h^,
^
70
>^
t^ng
s3
oc?rdn ghi
duyc,
tin sS xung
glaffl
xuong con
0,6
xung
trong
ns^c
glay,
6 ogt ol no^on
kbnc,
xung

nhi^
dl$n
tbl
ijang pb3n eye
troni::
xlnap
glu-a
tl boo tfo cbl
iienshaw
va tl
baa vpn dyng
tuy
sln^!;*
s
14
9
Myt
trong
nburng pbusmg
pbap xac
d^nh
co blfu
quo val
tro trung
gian
boa bpc cuo
GAB/*
lo dung cac
chit
dll kbang

onl
cua
OABA
h%
sit
hoan
toan*
kbdog
ahatii^
tbl, nhilu kbl xung
ahn
cua
neuron
con
t^g
bG^c
blnb
thi^4^« lac
gla cbo
s&c^,
trong dllu
klfn
ty
nbiSn
v5l
m^iz
m5c dy
nao do,
ncfrdn
da

c5u sy
blln
dll
trtf^n^^
thy coo cua ncfrdn vung cao giac cunc
nb§n tbIy
hlfu
qua cua
GAB^
b} mit
boon toon kbl cung
m(^t luc
cbo CABA
va blcuculln tac dyng
Ito acni'dntf
Kit
qua tbl
nt"bi§ffi
cua
Stcwat
va
Cf^ng
sy (149) cbo
th|y
ngoal
blcuculln
c^
co
myt lOal olcalolt
khac lo

IG,
11) cung
cnung oinh
tac
dpn^:
cus picrotoxin
ttfcfng
ty
nha
blcuculln trong quo trlnb blln dll
trii&ne
thy cam
Va tlnb
chit
detector cua
ncTcc
vung cac
giac &
tseo,
Kbl
x^^>
xlc
cac
cbIt
las
glao blfu
qua 5c cbl cua
GijBi
Sexkov
(55) dya

trong vo
nao»
i;o do penlcllln da
d*/yc
dung dl
too
nfaimg Old
blnb
dpog
klnb thyc
ngbl^o,
GJ
Qhi toe dyne
dll kbang cua
blcuiitlin
vo
plcrotcwrln
dli
v^
CAi^
khac
nbou«
Blcuculln co clu tao
tiKfug
ty
nbu phen
ttf
GAB/J
va cung aha
GABA,

ccr
cbl canb tranb (149) •
Soog
du tbeo
ctf
cbl nao, cac
cbIt
dll
kbonc
cung
locn glao
bl^u
qua 5c cbl cua
GAi>A
dll
v5l oOvQn nbif
r^au,
Dllu do
kbing djnb thStn
gia
tbt^ylt
cbo
ring
GABA
1Q
chit
trung
gian
5c chl trong vo nao,
Tron^i,

d^S
(K» m
2,2
,
10^5 M)
(112, 124).
Bhm^
kit
qua
ngblSn
c5u
v^
slnb ly
ncfron,
vl tl bao
hpc,
vl
di^c
ly hpc va
bIng klnii bien
vl
dlgn ttf
da
Isisang
d].nb
GABA
CO du
vioM
chuan
myt

cbl cuo te
bao triuxg
gian
dll
v5l
tl bao tbap lo
nhh
chat
trunc
glon hoc bpc
GABA,
bay
nol
each khac, 5e chl co ban
cbIt
G^BA.
vl v§y
x5
dpnc
G^B^
va
d|lc
bi$t
lo cac antagonist cua
no
trooB vl|c nghlSn ctfu
quo
trlnb,5c
cbl lo boan toon
byp

b^
noo,Cblnh
vl
v^y
ma
vlgc ncblon
c5u
Qg;uyen
tac
td
cb5o coc
agnr.
ncfrdn
duyc col
nbi7 cs^Jt bL?5c
quan
trpng
tronr
vlgc kbass
pbo
nbifnr
bl m§t
cua
b^
thing
thin
klnh.
ic^
Quan
nl|c9

•)
f^^*M^
«
coc
no^dn t§p
hyp
v5l
nhgu tbanb cac
cgt
hlnb try theo chiSu thing
d5n^
tpl Is coc
raddun, fcfidua glo
nbimg
tl bao
thin
klnb cung thyc
hlgn myt
cb5c
n^ng
tbdng
tin
nio do (16, 19,
^1,
27,
aB,
43,
54,
13I,
161).

luc do cac
|»ac
gla
trSn cbua
glal
tblch dtryc
cb5c
a&cs
cuo coc
cyt
ncrron nay*
^u
nh^
co sy phot
bifn
ra coc
ncfrdn trung glon 5c chc
trr^ig
vo nao, quon
nl^is
vl clu
true
cyt din din
dtfyc song
to*
»b5n^"
din
ll^u ngbien ctfu vh dlgn
sinh ly da cbi ro ,
kbl

tblnh glle
(14,
15) vo vung
vgc
d^n^^:,
(74,
75).
^^bu v0y
clu
true
c^t
la
d^c
dllts cbung
cua vo
noo#
Tbuylt
clu
true cyt
ngoy nay duyc
gpl
la tbuylt
tsddun,
Tbeo
^ountcastle
(43) dan
v}
ccr ban cua
oddun
lo vl oddun

b^
tbonb
mddun
lt?n,
cl clu
C90 ph5c tgp
bc/n,
l^ddun
l5n co
dpng phllo,day kbooog
TT;
i
V-W^#5J
«
17
30 - 2G0
Dcm,
doi ^^00 - 1000
ocm,
xuy§oc5 l5p li t5l
l^
V
cuo
vo
noo*
Trong oddun
l5n dlln
ro coc quo
trlnb
xu"

n^^uyen
tic
cau
ta^,
eac
mddun
l5n
co
cs?
s^
blnb
thai
tacmr;
del
ro,
nbtfn
cac vl
ludtiun - dc?n
vl
cb5c
nanf'
co* ban -co
kich cbuf5c 3G
oco
khdnf
phu hyp
v5l
sy
phan nbanh
cua

gan
5000 ncfron*
iJbimg
vl
©ddun v5l
dMn^
klnb
gen
30
oco cbl co
tbl
boo
i^hm
110-260
acfron (^3)*
5y
fflSu
tbuln tiny
chl co cbl
glal
chlcti Khi
phat
hlfn
ra coc tl boo 5c cbl
trong
jsddun
,
Cac
tl boo 5c
ctil difyc bav^s

c^c
mtcoc bt/ne
pban
•
Do
kit
qua cuo qua
trlnb
5c chl,
sy hung pbin
duyc
kbu
tru
trong
phafts
vl cuo
dc?n vJ
ch5c
nan^>
^^bt^
vvy
vl
ffiddun
lo
dcm
vJ.
cti5c
non^^
diPyc
hlnb

i-arln-
f odilla (122)
gop
phan
clol tnlch
vol tro
cuo
5c chl
trong
vo
noD del
v5l
t<^
ch5c
-
ch5c
nan^:
cuo coc
©cjdun.
Joe gla
da figrblen
c5u ty oi sy
pbjn nbonb
cuo tl boo rp
trong
cac
l5p
cuo
vunc vpn
dyng.

V
vS tl^l^^WssMM^'^'o
co coc
tl
boo
thop
nIo tronc
phleri.
^''bu
wy^by^^hl^^,^^*
t;o^
rp
-
tl
sif*
*-K1«
AZ
^^^
—
•**^'>c4f eye no^oti
c^:dv*^<9>-?blln^Ai^ae
d5rig.
a IC -
Klcb
tbi/^
vo hlnb
6ont,
cuo cnc
cyt
noy do

diwng
klnh
50 -• 100
oco, phu
byp
v'l
klcb
thir5c plmo nh^^nh
cuo
axon.
TI
boo rp
l5n o» l5p
III
tao
thirinh coc oddun co dgng pblln,doy
kboong 23-3O
oco, dal
£:ln
5G0
oco vo sau
t5
l5p
U din
1^
V,
Tuy cbo
din nay vSn cbua
co
oyt

boo
trun?^
fclon 5c chl, Cac tl
b^o
noy
dong val tro
quoo
urpni;
tron^^
vl0c v6 cb5c ciou hoo boat dyng
cua
oedUQ
v5i coc o5c
dy pii5c typ khsc
nhau,(16,
18,
49,
5G
,
52,
5^).
b)
gap
Q^h
C^aagp^lt)
B^n^^
phuc?n^
phop
s5 dyne nbllu dlfn eye (c;-5
vl

cua
coc
tin lil^u
htf&c^
t§o,
troofy
cac
t^
chSc uhln
klnh,
oa tr*/5c
blr
lo
tronr,
vo
bon c5u djil
noo, hlnb
thooh clc t&p quin nc?ron
v5l hlnb
done'
vo klcb
thi/'c
khac
nhou,
Tbap
Kogon
vo
c^tc
s^
(^,

true
coc
typ
quan ncfron
CO
nbl/ng d$c ctiea
co*
bat^
sau
s
- tidl c$p quia
boo
gom
coc ncfron
cun^;
I05I 0' trgng
tbsl bimg pblo kinoc nhou
vn nao tren
cun^r myc a5c
td
ch5c
cuo
cun*?
nbnn
xa.
th^ia chl lo
cung
cron
ffiyt
l5p

co
c5u true
tbeo
chllu dpc suit
be
day cuo vo
ooo,
-
Coc
t§p quin CO
klcb
tbtr5c
khac nhau,
pby
tauyc
vao
bon
chlu
va
tbdn^
so cuo
tin hlgu
h;?^5nf^
tao, voo
nic
thane
tlln
boo cuo
dyn^r
v^t*

blnb
thinnh
kbl co
klcb thlcb
hi^g
too ,
vl
VQy
no
kh<inr tSn tpl vinh
ctfu,
i^i
toe
dyn?.
cuo
s§t I09I
klcb thich
bu5n^
tfio
t^o
nen
coc
t^p
qu5n
co
hlnh done
va
kich tbu5c ttfcfng
&£;•
ho toe

ngu^/Sn
tac
xoc su*t» thln^r
kg,
ngbia
la sy
thom
gla
cuo
coc
nc/ron
voo clu
true
c^p
quin dlln
ro theo
nf^^uy^n tac
xac
sUwt,
con
higu
quo
boot dynr
cuo
t^p
qu»in Is
kit;
quo
tblot:
k§ hogt

khdne glon
cua
t^p
quIn,
-
till
quon
b|
ttfcfnt,:
toe
gltfo
coc
titntm
tronK-
cuni oyt
t§p qu5n
boo
giS
cun£;
1?
quon
hf dSng
pha*
Hf sl
tif^Vi^
quan
difcfn^
v5l sis trj tv^/^t doi
kho coo,
lig-tfjc Ipi hf

hlnh
thonh
coc
c^p
quan
ncTrdn
cho
din
noy
v8n
con
CO
nbuj]^
y
kiln
kboc nhou,
Tn,y nbien
cusif;
co
myt
00
quon
«
20
a
dllo
Chung
nhtf snu
s
- Coc

boo
naty i t<l
ch5c
ch?*n
klnb
tbip bfSti
cheo cung
phon
xg,
-
^c? nh
hlnh
uuoi trSn
chi lo
tlen
dl can
thlec
ban
^lu,
eon vol tro cd cb5c
ndn
coc
t^p
quIn Ipl tnuvc
vc coc dong
tin blgu
btf^nt;
t3®,
Coc
kit qun ne:bi§n

ph-^
cbuyc
voo quo trlnh 5c cbl xoy ro
cJ
vo noo,
'^o
trlnh noy chu
ylu
do toe
d^ng
cu?
coc
t*
bao 5c
ch*^
trunr cinn tgo non
(3i:)*
!Dheo
quon
dicD
cuo
coc
cac gla trin day tbl
odl tpp
quSn
ncfron
dt/y'c
coi
nhif
opt

0 dSy
ta
they cuori diem
oddun
vr
quon
dllmtgp
quan
g|p
nbou,
?roDg ©yt
chu^g
oyc
nao
do co thl bleu oddun
nbif ©yt
bloc ch5c
nan^v,
I^
con
CO
nJitfn^:
dieu kboc
biyt
ve chi
tilt,
coc
toe
gla
cue ca

co chl noy cho phep
glol
thlcb
du^jic pbSn
nao
nbtfng dgc
tlnb
co? ban
trong
bjpt
d^n$
tlch hyp cuo
by
noo,
Thoo
glo hlnb
uhonb
coc
d^c
tinh
noy khong
^hl thilu
dtryc vol
tro cuo coc quo trlnh
t;c
chl
tronf
vo noo.
uy-
•piii;

diiyc tile bonb bScg nbl§u pbtfcrng
pbap khac nhou*
V5l
pbuc^ng
pbap fc:bl
dlgn uhl cgooi vfi
too,
bong loat
cac
cdnc crlnb
(25,
33»
^^2,
56,
^Z^
63,
*?9,
127)
dS cfal
ro t
dif5l
anh
btfd^ng
cuo
bit
c5
oyu lo^l klcb chlch buSng t&n noo
,
dnp
5D£*

5c chl
&
m^t
sc
nc?roc.
co
bl^o ttryng
t3n£:
phot
xung:
trt^5c
kbl
tr:5
1^1
blnb
thiidn^
(pbo
bilnt;
pbin
sou 5c chl hoy lo
bun^
phin tbS
dp)*
0 ©yt ec It
ncfron,
5c
cbl phat
txlen
n^oy
sou kbl klcb thlcb

5c cbl,
3$c dlecs nay
quon
soc tbIy ^
coc tl boo
tbu^c tit
ca coc
vun{
vo
nio
kbl co
klcb tblch
d§c hi§u
xoy
ro*
Can c5 voo do
Serkov
(51,
52,
53,
5^^,
53) do
kit lu|nt
1-
tic
cbl lo thonh
pbSn
kbdn^^
tbl thllu dtfyc
tron^

tJc
chl xult
bign oyt
trong
trtf&ng
hyp tren gpl
la
5c
cbl
btf5ne
cao,
mQc
trong
nhung
dang 5c
cho
cuo vo nao,
M^t
trong
nbung phiK^ag
pbap
ngblgn e5u
co
blyu
qua quo
trlnb pbat
trlln
vo keo del cua 5c cbl
btf^ng tSo
la

bol ^^ch
chlch*
t^gir&l
dau
tlen dung
pbtfcfng
phop noy lo
Eruca
vo
c^nt;
sy
(bO) v5l snyc dlcb tlo bllu
trtf^n^
thy coo cuo
ncfrtKi
vm^^
cam giac
(y
oao,
l^lch
tblcb
htfng
duyc
dyt
voo
truct cOo
cua
trtfo'nfr chp
cotr,
klcb thlcb

1979
i-askln
vo
c^n^
sy (119) op dyng
pbtfc^g
pbap
uren
dl
n^lSn
ci/u anli
but^
cua 5c chl
del
v5l dap tfng
•^51^^"
cua ncfron kbl klcb thtcb dllu kblln nam
0 coc
vJ.
trl
kbac nhau trong
trtf^nc
thy
casi
vo
tbSi gion gltfa boi h kich
thich
cwu^
khac
nhau*

Tuy
vSy
traa:
cnc tbl
ngbl|o trSn cbtfo
co
odt ch&xg
olnh
tryc tllp noo
kb^nf:
d}.nh
5c chl
htftfnfv
turn co ban
chit
sau
xlnr^p,
i>l
glal
quyli;
van dl noy, coc nho
nghldn
c5u da
onus
9§t
trong hai pbtfcfng phop sou
t phucfnir
pbap gbl
dlgn
thl

too
3?o
tren ncfron kbl co
kich
tblch tryc tilp
ISn
bl
D;^t
vo
noo
(55), len cac
syl tbSn
klnh
vholomus - vd
noo(l02)
va do
bit
ky
oyt kich
thlcb
htf5nfi tao noo
(53,
5^*,
55,
56
,
62,
63,
€>4,
65, 102).

phIn
sou
xlnop
-
xung—Sxcltatoxy
Posta^^naptlc
potential - spike
(Ei^SP-splke),
L09I
2
% Blgn
thl
5c
chl sau xlnop
ilx'^'^
ijopl
3 t
do CO dlgn
cbl hung
pbIn
sou xlnop
•*
xung
—
dlyn
thl 5c cbl sou xlnop
(iiPSP ~
spike -
IPtJP)
Lopl 3 thtfmig ggp bcfn

xung),
Coc
n^hlGO
c5u tren
ncyron
vtaif:;
tblnh
^lac
vo
vunc
tb}.
glac
(53,
3^,
56)
oun^:
deu
gbl
di^
coc
logl
phon 5ng nol
tren,
Kbu
v^y
trons chonh phIn dlgn
thl
tron;:
te
boo

0,fc
-
1,2 osec (53, 55,
65,
IO2
,
15^).
sl llgu
noy thu dtfyc
khonc nhling 6
tl boo vung coo gioc
kbl klcb thich
ngogl
vl,
00
con
^
vuni,
tht
gloC
kbl
kich
tblcb doi
tht
vo
kbdnc tboy
ddl kbl klcb thlcb tlo
ubj
(55 )
Dllu do

tfc chl quo trlnh din
truyin
btf5ng
tfio*
Rb§n
tl
noy
cd thl lo tl
boo
trun^:;
gion
do
nb^c
t5l 5 vrStim IPSP xuau hlgn
trong
trtfStog byj>
nay lo
li^i^P
bal
xlnop, tronr do xlnap 5c chl
gltfa
tl bao
trunc iilon
vo tl
bao tbap da co toe
dynt ban
chl sy
Ion truy!n btfng pbIn
Qgay
trong te boo

5c
cbl
qu^t ngtfyc tpo
ro(130)*
Song
uheo Searkov
(55,
56)t thi
gltfo
5c cbl
btf5n=^
tStn
va 5c chl
qu§t ngtf^'c
co
nbimc^
dllo
kbnc
nbou.
t5c
chl
htf^m taa yu:1t
hlfn
ngoy tronr
l*n
klcb
cblch dau*
IFaP
cuo
^1

kich
t:ilch
ban^;
§m tbog
(7
- 23
msec),
IPBP glao
bin xuinc khi
klcb tblch
btfSng
too lo
nbimij lopc
klcb tblcb
llSn
tyc,
%tfyc Ipl IPiiP ^
tl boo
vunc
vd noo
v$n dyng
cbl xulc
blyn
kbl klcb thlcb
n^tfyc
cbllu voo bo chop
bloe
nbtfnci;
loat
klcb thlcb

khoc
blyt
t:dn,
tie
gla dl
din kit lugn
rang 5c
cbl
btf5ng tSo
kbdng pby
thuyc
voo 5c cbl
qu§t
ngtfyc,
Cac
tl boo trung
^lan thoo
gla voo
5c
cbl
qu|t ngijpyc
kbdn^^
a^a
trong
khSu dBn truyln btf5n(r
tlio*
«
25
*
lihtf v4y tronc

bL^n ^^ vS
l^^
^ tl bio
kbl
klcb
tblch
vSo
coc
dilo rSt nbd
ben
trorig
noo
ban^:
vl
dl§n eye
.
Pbtftfnc
phop noy
L^?1
tit l5 pb.fofnc pbSp klcb
thich trong
noo,
Asanuoa
vo
c^n^-
sy
{7!})
kbl
dun^^
xunj-

oco tbeo
htfc'ng
nao
ngaog
vo
xucn^:;
sSu phio
dtf5l
dlgn tbl gbl dtfyc
tbuye loyl n>dt
xlnap, con tren khoang
each
100 oco
dl^n
tal cbuyc
logl
do
xlnop*
irong
do
HSP
g§p
nbleu
htfn
ti^^'^
Loal
I?^
oyt xlnop co
ch^l
{-Ion

9^.,
133), Phon
clcb ttf<?nc
quon cheo
bo^t
tlnb
tpo
xun^T:
cuo
hoi ho^c
vol tl boo cung
o§t
luc, coc tac
glo cbo
thIy oah
hn'cna^;,
tfc
ebl gltfo cac tl
b*?o
xulc
blgn
tronf^
khoong 250-3y3
©co tbeo
bt^ng nIo
n^ong,
Sy khoc nbau
noy 00 the do
phucfng j
hop gbl

tbyc
cua
qua trlnh 5c chl trong nao,
Pht^jfng
pbap
dtfa
cac
chit
vao tl bao
bSng
vl dlgn dl la
pbtf(A3g
pbap
thuyn lyl bc^n
cd*
V5l oyt
Itfyai;:
nbd coc
chit
,
di^
quo vl dlgn
eye
tryc
tlop voo
te bdo do cho phep
quon

Trích đoạn Ttch btfp 7I iti>iir^, gtan

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