BỘ GIÁO DỤC VÀ ĐÀO TẠO BỘ Y TẾ

 





 

  












 AOAC (Association of Official Analytical
Chemists)

AP
Acid Propionic
ATVSTP

GC/FID (Gas chromatography with hydrogen
flame ionization detector)

HPLC (High performance liquid
chromatography)

LOD (Limit of Detection)

LOQ (Limit of Quantification)

MeCN
Acetonitil
MeOH
Methanol
PA

QC (Quality control)


49
AP 
50

53

55

56

57

59


Trang

16
Hình 1.2AP 
17

24
Hình 3.4: Ph
29

Hình 3.20
52
.21
53

54
Hình 3.23
58
Hình 3.24
58



1.  Hóa phân tích I
2.  Hóa phân tích II, tr. 123-
3. 

4. 
5. --BYT q
 .
6. - 

.
7.      ),      

8. 
.
9.   .    

.

electrophoresis methods", Journal of Pharmaceutical and Biomedical Analysis,
p.1249-1253.
22. Cao Ye (2005), A determination of propionic acid type antimicrobial preservatives
of feed by HPLCSouthwest China Journal of Agricultural Sciences, Vol. 18
(1), pp. 111-112.
23. Carlos Ibáñez  Analysis of total propionic acid in feed using headspace
solid-phase microextraction and gas chromatography, Journal of
Chromatography A, Vol. 1017, pp. 161-166.
24. Eiichi Ishikuro, Hiroshi Hibino, Tomoyoshi Soga, Hiroko Yanai, Hirokazu Sawada
        
 Journal of the food hygenic society of Japan, vol. 41(4),
pp.261.
25.           
efficacy of Propionic acid, Sodium propionate, Calcium propionate and
EFSA Journal 2011, vol.9 (12),
pp.2446.
26. Federal Agency for the safety of the food chain (2012), Determination of Propionic
acid, France.
27. Food safety and standards authority of India Ministry of Health and family welfare
Government of India (2012), Food additives, pp.40-41, New Delhi.
28. Hen Sebbag, Joachim Weiss, Zamir Manor, Olga Goldberg Oster, Yeoshua
Nachmani, Eitan JC Borojovich  Analysis Of Propionic And Acrylic
Acids By Reversed Phase HPLC With Anion Suppression And Conductivity
Analytica Chimica Acta, vol.551, pp.158 -169.
29. Japan Official method (2006), Determination of propionic acid, Calcium
propionate, Sodium propionate in food by Gas Chromatography.
30. Khaldun M. Al Azzam, Bahruddin S., Noor Hasani Hashim., Afidah Abdul Rahim.
       es and
        International
Food Research Journal, vol.17, pp.1107-1112.

40. Propionic Acid[http://www.ihs.com/products/chemical/planning/ceh/propionic-
acid.aspx], ng
41. 
[http://msdssearch.dow.com/PublishedLiteratureDOWCOM/dh_0105/0901b803
80105d3f.pdf?filepath=productsafety/pdfs/noreg/23300419.pd &fromPage=Get
Doc

 GVHD: TS. 
2013

H





 1
1.  3
1.1. B 3
 3
1.1.13] 3
 3
1.1.2.2. Nguyên nhân bên ngoài 4
 5
 5
 8
 9

 25
 25
2.3.2.2.  25
 25
 25
 26
2.3.3.3.  26
2.3.3.4.  26
) 27
2.3.3.7 27
 27
2.3.5 27
 29
3.1.
29
3.1.1.  29
3.1.2.  29
3. 30
3.1.4.  30
 GVHD: TS. 
2013

H

3. 31
 31
 31
 31
 32
 33


  m. C           
  
     ngày
nay ngày càng 
ích,
 công

Acid Propionic là c          
.   
vào 


13]. Tuy nhiên, n
 m lâu
 

[25], [39]. -BYT, gcho phép 
  
  
. acid Propionic  

5].


 GVHD: TS. 
2013

 Page 2


 Page 3

. 
1.1. B
1.1.1. 








(

.






1.1.2 [13]
1.1.2.1. Nguyên nhân nội tại
 
 



 GVHD: TS. 


 GVHD: TS. 
2013

 Page 5

-  :
Bacillus Subtilis, Bacillus mesentericus, Bacillus megaterium 



lên men các 
 Saccharomyces        Pichia, Hansenula,
Debaryomyces            Pichia,
Hansenula Debaryomyces
      Candida mycoderma      



 . Penicillium,    

Asper
 


a môi





. CH
3
Cl, CO
2
, SO
2
, F
2
, CCl
2
F
2
     

             

0

0
-
                 
-1
0
-2
0
-3
0
C



1 - 2 ngày
3 tháng
4

2-6
1 - 3 ngày
5

2  6
1  3 ngày
6

- 
2  5
(-10)  (-18)
2  3 ngày
2  3 tháng
7


3 ngày
8

- 
2  5
(-10)  (-18)
2  3 ngày
2 tháng
9


5  7 ngày
15

2  7
6 tháng

 GVHD: TS. 
2013

 Page 8


    -18
0
 
-40
0
-50
0
C v
nhanh.

-15
0
-20
0
-12
0
C
-15

0


0


              

 GVHD: TS. 
2013

 Page 9


v-75
0
C trong vòng 15-20 giây,
,7
0


 

0
-38
0
C trong 2-3


0


 Page 10






-90
0


* Dùn


-60
0

h



1.1.3.4. Áp dụng sức thẩm thấu để bảo quản



-
s

