Y HOC
VIET
NAM THANG 2 - SO 2/2014
TANG NONG DO
IL-8
HUYET THANH LIEN QUAN
Vai
TINH TRANG ROI LOAN LIPID
MAU
a
BENH NHAN
DAI
THAO
DU'O'NG TYP 2
Nguyen
Trong
Tai*
Nguyen
Thanh
Thiiy*,
,
Nguyen
Linh
Toan***
TOM TAT
Nghien cffu dinh
lUOng
ndng do IL-8 huyet thanh
va mpt so chi so lipid mau tren
d
40 benh nhan

p<0,001) trong mau va co
ti/flng
quan nghich vdi
nong do HDL-C
(r=-0,286,
p<0,05) d benh nhan DTD
typ 2.
ket
qua nay cho thay tang cao mffc IL-8 huyet
thanh co
lien
quan vdi tinh trang rdi loan lipid mau 6
benh nhan DTD typ
2,
Tff
khoa;
type 2 diabetes, T2D, IL-8, lipid parameters
SUMMARY
THE
CONCERNTRATION
OF SERUM
INTERLEUKIN-8
INCREASING ASSOCIATED
TO DISORDER OF LIPID PARAMETERS IN
PATIENT WITH TYPE 2 DIABETES
The levels of serum interieukin 8 (IL-8) and blood
lipid parameters of 40 patients with type 2 diabetes
(T2D) and 34 healthy control (HC)
mduviduals
were

with
disorder of
lipid parameters
in
patients with T2D.
*
Tr&dng Dai
hpc
YHa Npi
'* Dai
hpc
y Vinh
***
Hpc
vien
Quan y
Phan bien khoa hoc: TS, Ho Anh Sdn
I.
DAT VAN OE
Benh sinh
OTO
typ 2 la hau qua
eiia
qua
trinh tac dong qua lai phffc tap
ciia
sff khang
insulin va khiem khuyet tiet insulin; khong co
SLT
huy hoai te bao p mien

nguy cd benh ly khac nhau 5. Hien nay, mo m6
dffdc xem la mpt cd quan noi tiet va ehuyen hoa,
nhieu hormon do mo md san xuat
nhy:
adiponectin, secreted frizzled - related prdtein 5
(SFRP 5), leptin, interieukin
(IL)-l,
IL-6, IL-8,
IL-
18,
tumor necrosis factor anpha (TNF-
o),
adipsin,
resistin,
MCP-1,
PAI-1
da dffdc chffng
minh cd lien quan vdi rdi loan chuyen hoa, la cac
yeu td nguy cd
ciia
DTD typ 2, benh tim mach
IL-8 hoat dpng thong qua cac
thy
the dac hieu
tren be mat te bao, gay
kich
thfch dong tin hieu
eJAK (c-Jun
aminoterminal kinase) va
NF-KB

mSc
cac benh dai
thao dffdng,
tim
mach, huyet ap va hoan toan
khoe manh tai thdi diem nghien
cffu.
-
Nhdm
binh: 40 benh nhan DTD typ 2 (trong do
CO
20 benh nhan DTD
b/p
2 beo phi va 20 benh
nhan DTD
b/p
2 khong beo phi). Benh nhan
&ifqc
chan doan DTD typ 2 theo
tieu
chuan
ciia
To
chffe
y te the gidi (2010); kh6ng chpn nhffng
benh nhan dang dieu tn bang insulin, benh nhan
suy gan, suy
than,
dang mac cac benh npi
tiet

djch gan enzyme (ELISA, enzyme-linked
immunosorbent assay), sff dung cac
kit
eua
hang Orgenlum, Phan Lan,
qui
trinh theo
hffdng dan
eiia
nha san xuat.
2.3.
Xff ly so
lieu:
eac sd lieu phan tfch
ham phi tham so sff diing bang thuat toan
non-para
metric Mann-Whitney test, chi binh
phddng test, so sanh tffdng quan tuyen tfnh
sff dung phan mem
SPSS15.1.
So sanh sff
khac biet thong ke cd y nghia khi p < 0,05.
III.
KET QUA
3.1.
Dac diem lam sang benh nhan DTD typ 2
Bang
1. Dac dlem
ve
chi sd nhan trac cua ddi tffdng nghien cffu

77,6 ± 8,3
88,4 ± 6,7
0,88 ± 0,06
22,0
± 3,7
P
<
0,001
< 0,001
< 0,001
<
0,001
<
0,001
Nh$n xet: Cac
chi
sd trung binh ve can nang, vdng eo, vdng hdng,
WHR,
BMI
d nhdm benh nhan
DTD typ 2 cao hdn ro ret so vdi ngffdi binh thffdng (p<0,001).
3.2.
Tiiay
ddi ndng dd lipid mau
6
benh nhan OTO typ
Bang
2.
Nonq
do mot so chi so lipid

3,19 ± 0,82
P
<0,01
<
0,001
<
0,001
<0,001
Nh$n
x6t:
Nong dp cholesterol, triglycerid va LDL-C tang cao d benh nhan OTO typ 2 so vdi
ngiTcfl
binh thu'dng (p<0,01).
Ngi/cfc
lai, nong do HDL-C
giam
ro ret d benh nhan DTD
tip
2 so
vdi
ngu'di
binh
thu'dng
(p<0,001).
Y HOC VIET NAM THANG
2 -
SO
2/2014
3.3. Thay
dd'i

phan nhom
CO
va khong cd thira can beo phi (B) so vdi
ngUdI
binh thudng (p<0,001). Khong thay cd
sU
khac biet
ve nong dp IL-8 cua benh nhan OTO typ 2 cd
thiTa
can beo phi so vdi benh nhan khong cd
thCra
can
beo phi
(BJ
{p>0,05).
3,4. Mdi tu'dng quan cua IL-8 vdi nong do lipid mau d benh nhan OTO typ 2
Bang 4. M6I tudng quan cua nong dp IL-8 huyet thanh
vdi
mpt sd chi so lipid mau d benh
nhan OTO typ 2
IL-8
Tu'dng quan vdi
Cholesterol
(mmol/i)
Triglycerid (mmol/l)
HDL-C (mmol/l)
LDL-C (mmol/
0,479
0,397
<0,001

MCP-1,
PAI-1 ,
lam giam bai
tiet
adiponectin, SFRP-5
hau qua lam gia
tinh
nhay
ciia
te bao doi vdi
Insulin va gay de khang insulin 5.
O
benh nhan
DTD typ 2, IL-8 da dffdc chffng
minh
cd lien
quan den ed che khang insulin, nhff thong qua
cac thu the te bao IL-8
kieh
thich ddng tfn hieu
cJNK (e-Jun
aminoterminal kinase) va NF-kB
(nuclear factor-kappa B) lam tang cffdng san
xuat cae chat trung gian hoa hpc
ciia
viem, gay
roi loan bai tiet va lam roi loan ti'nh nhay cam
ciia
te bao doi vdi insulin tff dd gay khang insulin va
DTO.

dii
khdng
CO sy khac biet ve nong dp IL-8 d ca hai phan
nhdm DTD typ 2 beo phi so vdi DTO typ 2 khdng
beo phi (p>0,05), nhffng ed sff tang cao ro ret so
vdi ngydi binh thffdng (p<0,001) (Hinh
IB).
Cac yeu to thffa can beo phi, tang huyet ap,
glucose
ni^u,
hpi chffng ehuyen hda,.,. la nhffng
yeu to cho thay co lien quan den benh sinh DTO
typ 2, Nghien cffu
eiia
ehiing tdi cho thay sy thay
doi rat ro ret
ciia
cac chi sd lipid mau d benh
nhan DTD typ 2 (cd beo hoae khdng) so vdi
ngffdi binh thffdng (p<0,05). 6 benh nhan OTO
typ 2 va thira can beo phi hau het co
roi
loan
chuyen hoa lipid mau nhff tang cao ro ret ndng
dp cholesterol, triglycerid va LDL-C va giam
HOL-
C so vdi ngffdi binh thffdng (p<0,01). Tinh trang
roi loan lipid mau
d b?nh
nhan OTO typ 2 cd lien

nhat la nhffng trffdng hdp cd beo da cho thay ed
vai trd nhat dinh trong benh sinh
thii^
can beo
phi va OTO typ 2 [4,5,6,7]'.
V. KET LUAN
6
benh nhan OTO typ 2, nong dp IL-8 huyet
thanh tang eao rd ret so vdi ngddi khde manh
(p<0,01). Nong dp IL-8 cd tffdng quan thuan vdi
cholesterol, triglyceride, LDL-C va tffdng quan
nghich vdi HDL-C trong mau (p<0,05).
TAI LIEU THAM
KHAO
1.
Bremer A. and
Jialal
I. (2013), "Adipose Tissue
Dysfunction
in
Nascent Metabolic Syndrome",
Journal of
Obesity.
2. Hernandez
C,
et al. (2005), "Interleukin-8,
monocyte chemoattractant
protein-1
and
IL-10

Molecular Vision 2013; 19:1734-
1746.
5. Sandra
Galic,
et at. (2010), "Adipose tissue as
an endocrine
organ".
Molecular and Cellular
Endocrinology
3J6,
pp
129-139.
6. Seham A.
bou-Shousha,
Mona H.
Abd
El-
Megeed,
Hala
K. Sultan (2006), "Interieukin -
8, Ferritin and Soluble transfernn receptors in type
2
dibetes
mellitus".
The Egyptian journal of
immunology vol 13 (1), pp.
19
- 25.
7.
Straczkovi/ski M,