8
^
/r^
r^
A«i^^Vtfsajfr*M*»flivWS#^
(V-«eH?##.tii»V¥^Nifii^<V*N*yii^^
»-^

G6NG
KGHg B() NdNG
NGHISP*
PIMfl
£HGN
TR.ONO
BifeM
cAP
NHA
Ntrd^C
KCO4/06-W
I
Bi0
eAo
f
fee
10P
^^^^^^i^^^^B^^^^^
JO
KHOA
HOC VA
CONG
NGHE

XIN
NHU
DAU
TU
HUYET TRUNG TRAU
BO CHUNG P52
PHONG
BENH
TU HUYET TRUNG CHO
DAN
TRAU
BO
NUOI
6
VIET NAM"
Ma so: KC.04 DA 07/06-10
Chu
nhiem
da an
(kitten)
chu
tri
du*
an
^fcy
ten)
6NGGIAMD6C
TRAN
XUAN
H^NH

Hanh
phuc'
S6:JJ.S./DN-CTTY
TP.
HCM,
ngay
i^'thang
^Tnam
2010.
V/v:
De
nghi
ddnh gia
kit qua
de tai/d\e
an a cap nha
mc&c
Kinh
giri: - Ban chu
nhi^m Chu-ffng
trinh KC 04/06-10
- Van
phong
cac
ChiroTng
trinh KHCN
trgng diln c3p
Nha
nu-d-c
can cir

thien quy
trlah
san
xu^t vk
su"
dung \ic xin
nhu
dan tu huyet
r^'^ng
trau b6
chdng
P52 ph6ng
b^nh
tu huyet trung cho dan
trSu bd
nu6i d Viet Nam.
Ma
s6
du an: KC 04 DA 07/06-10
Thuoc: - Chuong trinh KHCN trong
diim cdp
Nha
nu&c "Nghien
ciJu,
phat
trien va rfng dung c6ng
ngfad
sinh hoc",
Ma
s6:

luong
va yeu cau theo
hop
dong;
2.
Bao cao nhan xet ve to
chiic
thuc hien cua ca
quan
chu tri
d§
tai, du an;
3.
Hop
d6ng
va thuyet minh de tai, du an kem theo;
4.
Thong tu ban hanh danh muc vac xin,
ch6 phim
sinh hoc, vi sinh vat. hoa
chit dung trong
thti
y dugc phep
luu
hanh tai Viet Nam do Bo NN&PTNT ban hanh
nam 2009;
giky chung
nhan dang ky san
xuit
thuoc

dk
tai,
dir
an;
7.
So nhat ky
dir
an;
8. Quyet dinh va bien ban danh gia cua Hoi dong danh gia cap ca so;
9. Van ban xac nhan ve su thoa thuan cua cac
t^c
gia ve
vice
sap xep thu tu ten
trong danh sach tac gia thuc hien
d6
tai, du ^n;
11.
Cac tai lieu khac
(n6u
c6).
So
lugng
ho so gom:
- 05
bg
(ban sao)
diy
du tai lieu ke tren;
- 08 bg (ban sao) cac tai lieu tren

TP.
HCM, ngay
^ thang .^"
nam 2010
BAO CAO VE VIEC HOAN THIEN
HO
SO
DANH GIA CAP CO
SO
I.
Nh&ng
thong tin chung
1.
Ten du an: Hoan
thi$n
quy trinh
sdn
xuat va
siJ
dung
vdc
xin nhu dau tu
huyet trung
trSu
b6
chiing
P52 ph6ng benh tu huyet
triing
cho dan
trSu

Hoi thu y Viet Nam.
5.
Thoi
gian danh gia: Bat dau:
09gia.
ngay
13/4/2010
Ka
thuc: 11 gia, ngay
13 M
/2010
II.
Noi dung da thuc hien theo ket
luan
cua hoi
d6ng
cip ca so:
1.
NhiJng
noi dung da bo sung hoan thien:
Du an da chinh
sila cAc iSi
in an, chinh ta, sap xep trat
tit
cac noi dung
trong bao cao hoan chinh theo gop y cua Hoi dong.
2.
NhQng van de bo sung moi:
- Bo sung nhOng hinh anh va giai thuong du an tham gia hoi chg
Techmart Viet Nam Asean + 3 vao thang 9/2009.

(HQ,
ten va chit ky}
XAC NHAN CUA
T6
cHtrc CHU
TRI
DE
TAI,
Dir
AN
,
chit
ky va dong
ddu)
'^SooioSr
PGS,TS.gi^J)^^
PHAM
QUANG
THAI
BAO CAO GIAI TRINH
MOT SO
VAN
DE
TAI
HQI
NGHI NGHIEM THU
CAP
CO
Sd
Du-

vi khuan P.multocida trong dieu kien nuoi cay
trong Fermenter
voi
cac thong so ve pH,
toe
do khuay dao, do thong
Idii
(do hoa tan oxy) da dugc chuan hoa.
Viec cai tien moi truong thuc hien trong du an nay da dam bao dugc
3 van de:
Tang hieu qua nuoi cay ciia vi khuan P.multocida,
chiing
P52
Moi
trirong
de che tao va de kiem soat ve mat chat lugng
Khong
CO sir
bien dong ve gia thanh san xuat moi tnrong
Thirc
te cho thay nong do vi khuan thu hoach dugc tang
len
khi nuoi
cay trong moi truong cai tien khong
nhitng
dam bao du tieu chuan de san
xuat vac xin nhu dau, ma con mang y
nghia
kinh te rat
Ion.

Cach che khang nguyen
diing
trong ky thuat
ELISA
phat hien
Ichang
the
THT trau bo? Tac gia c6 the dong y chuyen giao
ley
thuat ELISA?
Ky thuat ELISA
dliu
tien dugc chung toi phat trien de sir dung phat
hien khang the tu huyet triing heo (Septicaemic Pasteurellosis) vgi khang
nguyen
diing
chua vi khuan
Pasteurella
multocida serotype B:2. Ky thuat
nay dugc thirc hien tai khoa thu y (Vet School) truong dai hgc Queensland,
Australia
duoi
su huang dan cua giao su Alan Frost. Tir ket qua nay, chung
toi da chuan hoa de dung kiem tra
Idiang
the benh tu huyet triing trau bo
(Haemorrhagic septicaemia). Khang nguyen diing trong ky thuat nay la
khang nguyen chiu nhiet, diing chung VP 816 (hoac) HPKT99. Day la
chung dugc phan lap tir mot
6 djch

Tran Xuan Hanh
CONG TY TNHH
MOT
THANH
VIEN THUOC THU Y
TW
CONG HOA XA HOI CHU NGHIA VIE
I
NAM
Doc
lap - Ty do -
Hanh
phiic
TP.
HCM,
ngay
Jc
thang
,-?
nam 2010
DANH SACH TAC
GIA
THVC
HIEN
DE
TAI
KHCN/Dir
AN SXTN
CAP
NHA NlTdC

triing
trau
bo
chiing
P52
ph6ng
bfinh
tu
huyet triing
cho dan
ttau
bo
nuoi
S Vi$t
Nam.
Ma
s6
du
an:
KC 04 DA
07/06-10
Thuoc:
Chuong
trinh KHCN trong diem
cdp Nha
nuoc "Nghien
clJu,
ph£t tri^n
v4 iJng
dung cong

va
PTNT.
5.
Tac gia thuc hien
de
tai/dir
an tren gom
nhimg nguoi
c6 ten
trong danh sach sau
So
TT
1
2
3
4
5
6
7
8
9
Ch^c
danh khoa hoc, hoc vi,
ho va
ten
TS.
Tran Xuan Hanh
TS.
Nguyen Thien Thu
TS.

y TW
•
Cong ty thuoc
thii
y TW
Cong ty thuoc
thii
y TW
Cong ty thuoc thu y TW
ChCtky
1.)^''^-
'Wfz^^^'
/^t^£
-^
^y^-
•f'tfii-
V>
Chu
nhifm
de
tai/dy
an
(Ho,
ten
vd chu ky)
Thu
truong
to
chiic
chu tri

NlTOfC
1.
Thong tin chung:
1 Ten
dir
an:
Ho&n
thien quy trinh san
xurft
va
si
dung vac xin nhu
diu
tu
huy^t
triing
trSu
b6 chiing P52 ph6ng
bfinh
tu
huy^t triing
cho
dJn
trau bo
nuoi d
Vi6t
Nam
Ma
s8 dif
an: KC 04 DA 07/06-10

-
KSt
thuc (theo hgp
d6ng):
thang 2 nam
2010
-
Dirge
dieu chinh, gia han
(niu
c6) den: Khong
6. Tai lieu kem theo (neu c6): (van ban gia han, ket luan cua thanh tra, kiem
tra )
Dir
an khong phai gia han
II.
Nhan xet
vl t6
chirc thirc hien:
1.
Nhan xet
vk Ti6n
do thirc hien:
Thuc hien dung han:
Dir
an trien khai thuc hien dung han.
BChSng
thuc hien diing han (neu ro ly do
):
Khong.

C6NG
TY THUOC
THfl Y
TW CONG HOA
XA Hpl
CHU NGHIA VIET NAM
D9C
lap - Ty do - Hanh phuc
TP.
Ho
Chi
minh,
ngay
17
thang 03 nam 2010
BAO CAO THONG KE
KET QUA
THlTC
HIEN DE
TAI/DU
AN SXTN
I. THONG
TIN
CHUNG
1.
Ten de tai/du an: Hoan thien qui trinh san xua't va su' dung vac xin nhu
diu
tu
huye't
triing

Chiic
vu: Pho
tflng
giam d6c
Dienthoai:
T6
chvrc: 8 38225955 Nha rieng: Mobile: 0908356656
Fax: 08 38225060 E-mail: [email protected]
Ten to chirc dang cong tac: Cong ty TNHH mot thanh vien
thu6c
thu y
TW -NAVETCO
Dia chi
t6
chirc: 29
Nguyin
Dinh Chiiu,
Ql,
TP.
H6
Chi Minh
Dia chi nha rieng: 29
Nguyin
Dinh
ChiSu,
Ql. TP.
H6
Chi Minh
3.
To chirc chii tri de tai/dir an:

TiNH
HINH THl/C
HIEN
1.
Thdi
gian thirc hien de tai/dy ^n:
- Theo Hgp
dSng
da ky
kSt:
tir
thang 3
nam
2008
dSn
thang 2 nam 2010
- Thirc te thirc hien; tir thang 3/nam 2008 den thang 2 nam
2010
- Dugc gia han (neu c6): khong
2.
Kinh phi va sir dung
Itinh
phi:
a)
T6ng s6
kinh phi thuc hien: 6.695,876 tr.d, trong do:
+ Kinh phi he ttg tir SNKH: 2000 tr.d.
+ Kinh phi tir cac
nguSn
khac: 4.695,876 tr.d.

153
2.000
Thuc ti
a
Thoi gian
(Thang, nam)
9/2008
12/2008
3/2009
2010
at
tuac
Kinh phi
(Tr.d)
Cap 840
Cap 360
Cap 453
Cap 347
2.000
Ghi chu
(So de nghi
quyet toan)
502,440 tr.d
1.449,2
tr.d
48,36 tr.d
c) Ket qua sir dung kinh phi theo cac khoan chi:
Bdi
v&i du
an:

BChac
Tong cong *
Theo ke hoach
Tong
1.700
0
700
561,6
1.919,026
1.210
605,25
6.695,876
SN
KH
200
0
700
200
700
0
200
2.000
Nguon
khac
1.500
0
0
361,6
1.219,026
1.210

1.210
405,25
4.695,876
(*)
Chua tinh
kinh
phi
tic
von tu co de
SXso hegng
vac xin
vuat
du loan 4 trieu lieu.
- Ly do thay doi (neu c6):
3.
Cac van ban hanh chinh trong qua
trinh thurc
hien
de
tai/dy an:
(Liet ke cac quyet
dinh,
van ban cua ca
quan
quan ly
tir
cong
dogn
xac dinh
nhiem

2
3
4
So,
th&i
gian ban
hanh van ban
28/8/2007
27/8/2008
So
1691/QD-
BKHCN,
ngay 16/8/2007
S6
2060/QD-
BKHCN,
Ngay 24/9/2007
Ten van ban
Tom tat hoat dong KHCN
ciia
to chirc dang
ky
chii
tri DA
Don dang ky chu tri thirc hien
dir
an cap nha
nuoc
Quy6t
dinh phe duyet Danh muc

MasdKC
04/06-10
Ghi chu
Bo
KHCN
ban
hanh
Bo KHCN
ban
hanh
5
6
7
8
9
10
S6 2337/QD-
BKHCN
Ngay 18/10/2007
S6
137/QD-
BKHCN
Ngay 23/1/2008
So 293/QD-
BKHCN
Ngay 29/02/2008
S6
07/2008/HB-
DACT-KC04
DA 07/06-10

img dung cong nghe sinh hoc". Ma
S6KC
04/06-10
Quy^t
djnh phe duyet kinh phi 07 de tai, 02
dir
an SXTN bit
dlu
thirc hien nam 2008
thuoc Chuong trinh KH&CN trong diem
cap
Nha nuoc giai doan
2006-2010
"Nghien
cim, phat trien
va
img dung cong nghe sinh
hoc".
Ma so KC
04/06-10
Hgp dong nghien cim khoa hoc
va
phat trien
cong nghe
Ban qui che chi tieu kinh phi Du an SXTN
"Hoan thien qui trinh san xuat va
sii:
dung
vac xin nhu dau tu huyet triing trau bo
chUng

ban hanh
(NAVETCO)
Co quan chii tri
diran
(NAVETCO)
4.
To
chu-c
phoi hop thuc hien di tai,
du-
an: Khong
S8
TT
1
Ten to chirc
dang ky theo
Thuyit minh
Ten to chirc da
tham gia thirc
hien
Ndi dung
tham
gia
chuyiu
Sim phSm
cha
yeu
dat duac
Ghi
chii*

tham gia
thivc
hiin
Tran Xuan
Hanh
Pham Quang
Thai
To Thi Phan
Nguyen
Thien Thu
D6
Van
Dung
Vo Cong
Minh
}e
tai,
duan:
Npi
dung tham gia
chinh
Chu
nhiSm:
To
chu'c,
quan iy,
thyc
hi6n triin
khai
dU

HoEln
thien qui
ttinh ki^m nghi§m
cac chi tieu vacxin
bang
phUPng
phap
thay
thS'
va trong
tai.
Phu trach
tri^n
khai
san
xu3't
vac xin qui
m6 cong nghiep
San pham
chuyiu
dat dugc
To chuc thuc hien
day du cac noi
dung cua du an,
dung tien dp.
Hoan tat bao cao
To chuc phat trien
mang
luoi
va Tieu

chu*
7
8
9
Pham
Hao
Quang
Pham Hao
Quang
Nguyen van
Dung
Nguyen
Tang Kien
Xay
dtfng phUdng
phap kiem tra
mien djch bao ho
dan gia
sue dUdc
tiem vacxin bang
ky thuat ELISA,
Thu nghiem thuc
dia danh gia an
toan va hieu
luc
vac xin
Phu trach thiet bi
Thiet lap qui trinh
ky thuat ELISA
dung phat

TT
1
2
3
4
5
6
7
Theo ke hoach
(Noi dung,
thai
gian,
kinh
phi,
dia
diem)
Viing
Tay Nguyen
Viing
mien Trung
Viing Tay Nam bp
Viing
Dong Nam bp
Phia
Bac
Hoi nghi khoa hoc co so
nghiem thu tien dp
H3i d6ng
KHCN danh gia
nghiem thu cap co so

•
Hoi (hao khoa hoc.
dien
tra khao
adi
trong
nu&c
vd nuac
ngoai)
Sd
TT
1
2
3
4
5
6
7
Cac noi dung, cong viec
chuyiu
(Cac mSc danh gia chit yeu)
Hoan thien qui trinh cong nghe
san xuat vac xin THT trau bo
nhu dau chiing P52
6
qui mo
cong nghiep.
Hoan thien qui trinh
ki^m
nghiem vac xin THT trau bo

chii
qui trinh san
xuat, su dung thanh thao thiet bi
san xuat
Thiyi
gian
(Bat
ddu,
ket thiic
-
thang
nam)
Theo ke
hoach
4-12/2008
6-12/2008
-12/2009
6-12/2008
6/2008
-
12/2009
6/2008
-
12/2009
12/2009
12/2008
Thuc te
dat duac
12/2008
12/2008

Thien Thu
BS.
Vo Cong
Minh
TS.Tran
Xuan Hanh.
BS.
To Thi
Phin.
KS.
Nguyen
Tang Kien
- Ly do thay
d6i
(neu co):
III.
SAN PHAM KH&CN CUA DE TAI,
Dl/
AN
1.
San
phSm
KH&CN da tao ra:
a)
San
phim Dang I:
Sd
TT
1
Ten san pham vd

Hoan thien qui trinh
cong nghe san xuat
vac xin THT trau bo
nhu dau chung P52
6
qui mo cong
nghiep.
Hoan
thiSn
qui trinh
kiem nghiem vac
xin THT
trau
bo nhil
d^u
chung P52.
Xay dung phuang
phap danh gia mien
dich va bao
h6 ciaa
vac xin trong dieu
kien thuc
te'
bang ky
thuat ELISA.
Yeu
can
khoa
hpc
chn dat

phuong phap ELISA va
phuang phap bao ho
thu dong tren chupt khi
ti6n
hanh kiem tra mien
Thuc te
dat duac
Qui trinh san xuat
vac xin vo boat tu
huyet trung trau
bo
nhQ
dau chung
P52 (qui mo cong
nghiep)
Qui trinh kiem
nghiem vac xin vo
hoat tu huyet
trung trau bo nhu
dau chung P52
Qui trinh ky thuat
ELISA dung phat
hien khang the
Pasteurella
multocida
serotype
B:2
Ghi chu
Dat theo
dang ky

ngoai theo yeu cau van
chuyen.
- Danh gia theo doi
nhiSt d6
vh.
dilu ki6n
van
chuyen.
- Xac dinh doi
tuong
tiem phong vac xin
- Qui dinh lieu tiem
duong tiem vac xin
- Bao quan vac xin
trong qua trinh tiem
- Bao
bi,
nhan mac, han
diJng,
each
tidm,
dudng
tiSm,
lilu
tifem.
Qui trinh bao
quan vac xin vo
hoat tu huyet
triing trau bo nhu
dau chung P52

6
trau bo sau khi
tiem vac xin tu huyet
triing trau bo bang
phuong phap ELISA
Bao cao
tdng kSt
du an
Yeu cau khoa
hpc
can dat
Theo
kl hoach
1
1
Thuc te
dat duoc
1
1
SS luang,
noicdng
bo
(Tap
chi,
nha
xuat ban)
Khoa
hgc
ky
thuat

thiic)
01 da
tot
nghiep 2009
•
Ly do thay doi (neu
c6):
e)
Th6ng
ke danh muc san pham KHCN da dugc ung dung
S6
TT
1
2
3
4
5
6
Ten
kit qua
da
dirofc
ung dung
Qui trinh san xuat vac
xin vo hoat tu huyet
trung trau bo nhu dau
chiing P52 (qui mo cong
nghiep)
Qui trinh kiem nghiem
vac xin vo boat tu huyet

ten.
dia
chi nai ung dung)
Cong ty TNHH
mot thanh vien
thuoc thu y TW
Cong ty TNHH
mot thanh vien
thuoc thu y TW
Cong ty TNHH
mot thanh vien
thuoc
thii
y TW
Cong ty TNHH
mot thanh vien
thuoc
thii
y TW
Cong ty TNHH
mot thanh vien
thuoc thu y TW.
Cac chi
cue thii
y
Cong ty TNHH
mot thanh vien
vao thuc te
Kit qua
so'bo

van chuyen vac
xin tai
cac chi cue
thii
y va
tii
cac chi
cue
toi dia diem
tiem phong
Cac chi
ciic thii
y va
nguoi
sii
dung vac
niing
trSu
bo nhu dau
chung P52
thuoc thu y TW.
Cac chi
cue thii
y
xin de tiem phong
2.
f)anh
gia ve hieu qua do de tai,
du'
an mang lai:

-
VS
cong nghe: Vac xin dugc san xuat dat cong nghe tien tien dugc ap dung
o
nhieu nuoc tren
thi
gioi.
b) Hieu qua ve kinh te xa hoi:
Do
nhijng iru
viet
ciia
vac xin nhQ dau tu huyet tning trau bo chiing P52 da
dugc nghien
cuu
trong du an, loi ich
ciia
vac xin the hien
cii
the
nhir
sau:
+ Giam so
Ian
tiem phong tit
1
nam 2
Ian
xuong
1

(d6ng)
Chi
phi/con/
nam
(d6ng)
Ghi
chii
keo phen
Vac xin
nhu dau
1.300
1.424
2
1
1,5
2.000
2,000
2.000
6.600
3.424
5.136
Viing
it
de doa
Viing CO
nguy
eg
cao
So lugng trau bo ca nuoc hien co khoang 8 trieu con, nhu vay neu ty le tiem
phong

1
Lin
2
Lan 3
Th&i
gian
thuc hien
11/11/2008
29/5/2009
11/12/2009
Ghi chii
(Tom tat ket
qua.
lie!
luan chinh,
ngicai
chii tri )
DlT an dugc to chirc trien khai
nghiem tiic, khoa hgc cac noi dung
de ra. Da hoan thanh 3 noi dung:
Hoan thien qui trinh cong nghe san
xuat vac xin nhii dau qui mo cong
ngiep;
SX dugc 927.125
liSu
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qui tring va van hanh thiet bi.
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ky dung tien do va chat lugng. Da

da^
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so lugng san pham.
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an o
c8p
Nha
nude.
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(Ho
ten,
chu ky)
Thu truong to chu'c chu tri
'n,
chu:
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TAT KET QUA
Nham han che nhugc diem cua vac xin THT trau bo keo phen, vac xin

san xuat thir nghiem nay.
Du an thuc hien va hoan thanh 6 noi dung, bao gom: i/ Hoan thien qui
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qui mo
cong nghiep; ii/ Hoan thien qui trinh kiem nghiem vac xin THT nhii dau; iii/
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nliQ
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Xay
dung phuong phap kiem tra mien djch de danh
gia miln dich ciia dan gia
site
dugc tiem phong vac xin THT; vi/ Thu nghiem
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Kit
qua cua du an chi ra rang vac xin THT trau bo nhu dau chiing
P52
da
dugc san xuit thanh cong tai Cong ty thuoc thu y TW - NAVETCO, cong